FlyBase Allele Report: Dmel\Lam[KK102399]

General Information

Symbol

Dmel\Lam^KK102399

Species

D. melanogaster

Name

FlyBase ID

FBal0231774

Feature type

allele

Associated gene

Dmel\Lam

Associated Insertion(s)

Carried in Construct

P{KK102399}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102399}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102399

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of myopathy

CEA

(Oyston et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | oogenesis, with Scer\GAL4^c306

(Penfield and Montell, 2023)

abnormal cell migration | oogenesis, with Scer\GAL4^fru.PU

(Penfield and Montell, 2023)

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

decreased size | oogenesis, with Scer\GAL4^c306

(Penfield and Montell, 2023)

uncoordinated, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

Phenotype Manifest In

border follicle cell, with Scer\GAL4^c306

(Penfield and Montell, 2023)

border follicle cell, with Scer\GAL4^fru.PU

(Penfield and Montell, 2023)

eye, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

eye, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

nucleus | oogenesis, with Scer\GAL4^c306

(Penfield and Montell, 2023)

Detailed Description

Statement

Reference

Expression of Lam^KK102399 results in: weak uncoordinated adults with rough eye (with the Scer\GAL4^Act5C.PI driver), small rough eye (with Scer\GAL4^ey.PH) or just slightly rough eye phenotype (with Scer\GAL4^GMR.PF). Expression controlled by Scer\GAL4^nub.PK or Scer\GAL4^en.PU has no overt adult phenotype.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Lam^KK102399, Scer\GAL4^c306 has abnormal cell migration | oogenesis phenotype, suppressible | partially by LamC^UAS.cSa, Scer\GAL4^c306

(Penfield and Montell, 2023)

Suppressor of