FlyBase Allele Report: Dmel\eas[KK102681]

General Information

Symbol

Dmel\eas^KK102681

Species

D. melanogaster

Name

FlyBase ID

FBal0231935

Feature type

allele

Associated gene

Dmel\eas

Associated Insertion(s)

Carried in Construct

P{KK102681}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102681}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102681

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

abnormal size | adult stage, with Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

female germline stem cell, with Scer\GAL4^Lsp2.3.1

(Matsuoka et al., 2017)

optic cartridge | adult stage, with Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

Detailed Description

Statement

Reference

5-days old adults expressing eas^KK102681 under the control of Scer\GAL4^GMR.PFa display bloated photoreceptor cell axon terminals and incomplete optic cartridges.

(Tsai et al., 2019)

Expression of eas^KK102681 under the control of Scer\GAL4^Lsp2.3.1 (using tub-Gal80[ts] to limit expression to adulthood) does not induce cell death in either germaria or vitellogenic stage follicles and while it does not affect the proliferation of the germline stem cells it leads to significant increase in the rate of their loss over time.

(Matsuoka et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PFa, eas^KK102681 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by SREBP^UAS.Exel, Scer\GAL4^GMR.PFa

(Tsai et al., 2019)

Scer\GAL4^GMR.PFa, eas^KK102681 has abnormal size | adult stage phenotype, non-suppressible by SREBP^UAS.Exel, Scer\GAL4^GMR.PFa