FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fdx2KK102957
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General Information
Symbol
Dmel\Fdx2KK102957
Species
D. melanogaster
Name
FlyBase ID
FBal0232123
Feature type
allele
Associated gene
Dmel\Fdx2
Associated Insertion(s)
Carried in Construct
P{KK102957}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK102957}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK102957
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4da.G32-mediated expression of Fdx2KK102957 results in larval growth defects and strong larval lethality - only 55% of mutants reach third larval instar stage, and less than 1% form pupae. Larvae are smaller and weigh less than controls. Tracheal defects are observed in these larvae, with signs of necrosis. The defective pupariation is not rescued by feeding with 20-hydroxy-ecdysone.

      Scer\GAL4phm.PU-mediated expression of Fdx2KK102957 results in larval growth defects and lethality at the third instar stage, with a complete lack of pupariation. Tracheal defects are observed in these larvae, with signs of necrosis. Pupariation is only weakly rescued by feeding with 20-hydroxy-ecdysone.

      (Palandri et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG1319KK102957
      Fdx2KK102957
      Name Synonyms
      Secondary FlyBase IDs
        References (2)