FlyBase Allele Report: Dmel\Galt[KK102974]

General Information

Symbol

Dmel\Galt^KK102974

Species

D. melanogaster

Name

FlyBase ID

FBal0232137

Feature type

allele

Associated gene

Dmel\Galt

Associated Insertion(s)

Carried in Construct

P{KK102974}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102974}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102974

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of galactosemia

CEA

(Jumbo-Lucioni et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PU

(Jumbo-Lucioni et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

(Jumbo-Lucioni et al., 2014)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PU

(Jumbo-Lucioni et al., 2014)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

(Jumbo-Lucioni et al., 2014)

NMJ bouton | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

NMJ bouton | third instar larval stage, with Scer\GAL4^elav.PU

(Jumbo-Lucioni et al., 2014)

NMJ bouton | third instar larval stage, with Scer\GAL4^how-24B

(Jumbo-Lucioni et al., 2014)

synapse | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

synapse | third instar larval stage, with Scer\GAL4^elav.PU

(Jumbo-Lucioni et al., 2014)

synapse | third instar larval stage, with Scer\GAL4^how-24B

(Jumbo-Lucioni et al., 2014)

Detailed Description

Statement

Reference

Expression of Galt^KK102974 under the control of Scer\GAL4^da.G32, Scer\GAL4^elav.PU or Scer\GAL4^how-24B results in L3 NMJs exhibiting synaptic structural over-elaboration, with a significant increase in synaptic bouton number and synapse branch number; but mean excitatory junction current amplitude is not significantly different in larvae expressing Galt^KK102974 under the control of Scer\GAL4^da.G32, as compared to controls.

(Jumbo-Lucioni et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100025

P{KK102974}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9232^KK102974

Galt^KK102974

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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