FlyBase Allele Report: Dmel\Amnionless[KK103998]

General Information

Symbol

Dmel\Amnionless^KK103998

Species

D. melanogaster

Name

FlyBase ID

FBal0232666

Feature type

allele

Associated gene

Dmel\Amnionless

Associated Insertion(s)

Carried in Construct

P{KK103998}

Also Known As

UAS-dAmn^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK103998}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK103998

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cardiomyopathy

CEA

(Hartley et al., 2016)

model of kidney disease

CEA

(Zhang et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

increased speed of aging, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

short lived, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

Phenotype Manifest In

adult brain, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

adult heart, with Scer\GAL4^Ugt36A1.PK

(Hartley et al., 2016)

indirect flight muscle cell, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

larval pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Zhang et al., 2013)

Detailed Description

Statement

Reference

RNAi knock-down of Amnionless driven by Scer\GAL4^Dot.PK impairs nephrocyte function and causes heart function defects (longer heart period, higher arrhythmia index).

(Hartley et al., 2016)

Scer\GAL4^Dot.PK-mediated expression of Amnionless^KK103998 reduces the normal accumulation of ANF-RFP (expressed via Rnor\ANF^{Mhc.T:Disc\RFP}) in pericardial nephrocytes.

(Zhang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104099

P{KK103998}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Amnionless^KK103998

CG11592^KK103998

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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