FlyBase Allele Report: Dmel\stw[KK105443]

General Information

Symbol

Dmel\stw^KK105443

Species

D. melanogaster

Name

FlyBase ID

FBal0233563

Feature type

allele

Associated gene

Dmel\stw

Associated Insertion(s)

Carried in Construct

P{KK105443}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK105443}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK105443

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color | adult stage | male, with Scer\GAL4^42D04.A

(Massey et al., 2019)

abnormal body color | adult stage | male, with Scer\GAL4^42D04.E

(Massey et al., 2019)

abnormal body color | adult stage | male, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

abnormal mating | male, with Scer\GAL4^42D04.A

(Massey et al., 2019)

abnormal mating | male, with Scer\GAL4^42D04.E

(Massey et al., 2019)

abnormal mating | male, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

visible | adult stage, with Scer\GAL4^42D04.A

(Massey et al., 2019)

visible | adult stage, with Scer\GAL4^42D04.E

(Massey et al., 2019)

visible | adult stage, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

Phenotype Manifest In

aedeagus, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

sex comb, with Scer\GAL4^42D04.A

(Massey et al., 2019)

sex comb, with Scer\GAL4^42D04.E

(Massey et al., 2019)

sex comb, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

sex comb tooth, with Scer\GAL4^GMR42D04

(Massey et al., 2019)

Detailed Description

Statement

Reference

The expression of stw^KK105443 under the control of Scer\GAL4^GMR42D04 severely decreases male mating success (males fail repeatedly to grasp the female abdomen with their sex combs when attempting to mount and copulate), severely decreases sex comb melanization (the sex combs appear translucent) and results in thinner and smoother sex comb teeth, as compared to controls. These flies also lack aedeagus melanization.

Expression under the control of either Scer\GAL4^42D04.A or Scer\GAL4^42D04.E, but not under the control of Scer\GAL4^42D04.C or Scer\GAL4^42D04.D, severely impairs both the male copulation success and sex comb melanization, but does not affect aedeagus melanization.

(Massey et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101687

P{KK105443}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG42345^KK105443

laccase2^KK105443

stw^KK105443

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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