FlyBase Allele Report: Dmel\spi[KK105786]

General Information

Symbol

Dmel\spi^KK105786

Species

D. melanogaster

Name

FlyBase ID

FBal0233780

Feature type

allele

Associated gene

Dmel\spi

Associated Insertion(s)

Carried in Construct

P{KK105786}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK105786}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK105786

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | third instar larval stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Rahn et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of spi^KK105786 under the control of Scer\GAL4^{elav.Switch.PO} from immediately after hatching onwards (using mifepristone to control the timing of expression) results in significantly reduced olfactory learning ability in third instar larvae. These larvae show normal gustatory preference responses to fructose and to quinine and show normal olfactory responses to amyl acetate and to 1-octanol.

(Rahn et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

spi^KK105786/Scer\GAL4^Su(H).GBE is a suppressor | partially of neoplasia phenotype of Sox21a⁶

(Zhai et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

spi^KK105786/Scer\GAL4^Su(H).GBE is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a⁶

(Zhai et al., 2015)

NOT Suppressor of

Statement

Reference

spi^KK105786/Scer\GAL4^NP0001 is a non-suppressor of adult anterior midgut epithelium phenotype of Sox21a⁶

(Zhai et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of spi^KK105786 in enteroblasts under the control of Scer\GAL4^Su(H).GBE reduces tumor formation in the anterior midgut of Sox21a⁶ mutant flies. The reduction is not significant when spi^KK105786 is expressed in enterocytes under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Zhai et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103817

P{KK105786}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spi^KK105786

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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