FlyBase Allele Report: Dmel\cos[KK106270]

General Information

Symbol

Dmel\cos^KK106270

Species

D. melanogaster

Name

FlyBase ID

FBal0234120

Feature type

allele

Associated gene

Dmel\cos

Associated Insertion(s)

Carried in Construct

P{KK106270}

Also Known As

UAS-Cos2 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK106270}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK106270

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^da.G32

(Lee et al., 2018)

increased cell number | oogenesis | somatic clone, with Scer\GAL4^Act.PU

(Dai et al., 2017)

Phenotype Manifest In

adult midgut, with Scer\GAL4^da.G32

(Lee et al., 2018)

basal stalk | somatic clone, with Scer\GAL4^Act.PU

(Dai et al., 2017)

lipid droplet | adult stage, with Scer\GAL4^da.G32

(Lee et al., 2018)

stalk follicle cell | somatic clone, with Scer\GAL4^Act.PU

(Dai et al., 2017)

Detailed Description

Statement

Reference

Expression of cos^KK106270 under the control of Scer\GAL4^da.G32 leads to a significant decrease in lipid droplets (ie number, size and relative cellular content) in the adult midgut, as compared to controls.

(Lee et al., 2018)

Somatic cell clones that express cos^KK106270 under the control of Scer\GAL4^Act.PU show a significant increase in the number of stalk cells, as compared to controls.

(Dai et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Act.PU, cos^KK106270 has increased cell number | oogenesis | somatic clone phenotype, enhanceable | somatic clone by Axn^S044230/Axn^S044230

(Dai et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/cos^KK106270 is an enhancer of increased cell number | oogenesis | somatic clone phenotype of Axn^S044230

(Dai et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/cos^KK106270 is a suppressor of abnormal developmental rate | somatic clone phenotype of Ubr3^B

(Li et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Act.PU, cos^KK106270 has stalk follicle cell | somatic clone phenotype, enhanceable | somatic clone by Axn^S044230/Axn^S044230

(Dai et al., 2017)

Scer\GAL4^Act.PU, cos^KK106270 has basal stalk | somatic clone phenotype, enhanceable | somatic clone by Axn^S044230/Axn^S044230

(Dai et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/cos^KK106270 is an enhancer of stalk follicle cell | increased number | somatic clone phenotype of Axn^S044230

(Dai et al., 2017)

Scer\GAL4^Act.PU/cos^KK106270 is an enhancer of basal stalk | somatic clone phenotype of Axn^S044230

(Dai et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/cos^KK106270 is a suppressor of photoreceptor neuron | somatic clone phenotype of Ubr3^B

(Li et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Follicle cell clones both homozygous for Axn^S044230 and expressing cos^KK106270 under the control of Scer\GAL4^Act.PU exhibit a more severe supernumerary stalk cell phenotype than either single mutant clones.

(Dai et al., 2017)

Expression of cos^KK106270 under the control of Scer\GAL4^Act.PU rescues the delayed photoreceptor differentiation phenotype of Ubr3^B/Ubr3^B mutant clones.

(Li et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108914

P{KK106270}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cos^KD

(Dai et al., 2017)

cos^KK106270

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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