FlyBase Allele Report: Dmel\Irk3[KK107031]

General Information

Symbol

Dmel\Irk3^KK107031

Species

D. melanogaster

Name

FlyBase ID

FBal0234660

Feature type

allele

Associated gene

Dmel\Irk3

Associated Insertion(s)

Carried in Construct

P{KK107031}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107031}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107031

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

(Tsubouchi et al., 2012)

partially lethal - majority die, with Scer\GAL4^da.G32

(Dahal et al., 2012)

short lived | nutrition conditional, with Scer\GAL4^Ilp2.PW

(Enell et al., 2010)

visible | adult stage, with Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

Phenotype Manifest In

wing, with Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

wing hinge, with Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

wing vein, with Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

Detailed Description

Statement

Reference

Ubiquitous expression of Irk3^KK107031 under the control of Scer\GAL4^da.G32 results in 98% lethality.

100% of wings from flies expressing Irk3^KK107031 under the control of Scer\GAL4^Bx-MS1096 show severe wing vein defects. 40% of wings also show a reduction in wing size and hinge defects.

(Dahal et al., 2012)

Male flies expressing Irk3^GD1764 under the control of Scer\GAL4^Ilp2.PW display a strongly diminished survival at starvation compared to controls.

(Enell et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101174

P{KK107031}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Irk3^KK107031

Irk3^RNAi-1

(Charlton-Perkins et al., 2017)

Irk3^RNAi

(Weiss et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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