FlyBase Allele Report: Dmel\Art8[KK107174]

General Information

Symbol

Dmel\Art8^KK107174

Species

D. melanogaster

Name

FlyBase ID

FBal0234769

Feature type

allele

Associated gene

Dmel\Art8

Associated Insertion(s)

Carried in Construct

P{KK107174}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107174}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107174

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Kennedy's disease

modeled by Hsap\AR^Q52.UAS

(Scaramuzzino et al., 2015)

modeled by Hsap\AR^Q12.UAS

(Scaramuzzino et al., 2015)

DOES NOT ameliorate Kennedy's disease

modeled by Hsap\AR^{Q65.S215A.S792A.UAS}

(Scaramuzzino et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Art8^KK107174 under the control of Scer\GAL4^GMR.PU does not result in any obvious ommatidial degeneration.

(Scaramuzzino et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Hsap\AR^Q52.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Hsap\AR^Q12.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

NOT Suppressor of

Statement

Reference

Art8^KK107174, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Hsap\AR^{Q65.S215A.S792A.UAS}, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\AR^Q52.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium phenotype of Hsap\AR^Q52.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\AR^Q12.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Art8^KK107174, Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium phenotype of Hsap\AR^Q12.UAS, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

NOT Suppressor of

Statement

Reference

Art8^KK107174, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\AR^{Q65.S215A.S792A.UAS}, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Art8^KK107174, Scer\GAL4^GMR.PU is a non-suppressor of ommatidium phenotype of Hsap\AR^{Q65.S215A.S792A.UAS}, Scer\GAL4^GMR.PU

(Scaramuzzino et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Art8^KK107174 partially suppresses the ommatidial degeneration seen in flies expressing Hsap\AR^Q52.Scer\UAS or Hsap\AR^Q12.Scer\UAS under the control of Scer\GAL4^GMR.PU.

Co-expression of Art8^KK107174 and Hsap\AR^Q0.Scer\UAS under the control of Scer\GAL4^GMR.PU does not result in ommatidial degeneration.

Co-expression of Art8^KK107174 fails to suppress the ommatidial degeneration seen in flies expressing Hsap\AR^{Q65.S215A.S792A.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Scaramuzzino et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100228

P{KK107174}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Art8^KK107174

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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