FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\FASN1KK107330
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General Information
Symbol
Dmel\FASN1KK107330
Species
D. melanogaster
Name
FlyBase ID
FBal0234870
Feature type
allele
Associated gene
Dmel\FASN1
Associated Insertion(s)
Carried in Construct
P{KK107330}
Also Known As
UAS-FAS-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK107330}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK107330
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  heart conduction disease
      modeled by eas2
      (Lim et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing CG3523KK107330 under the control of Scer\GAL4αTub84B.PL show early larval lethality on a 20% yeast diet, but supplementation of the diet with 15% sucrose partially rescues the lethality, allowing pupation.

      (Havula et al., 2013)

      Expression of CG3523KK107330 under the control of Scer\GAL4Bx-MS1096 results in slight curling of the wing.

      (Friedman et al., 2011)

      Expression of CG3523KK107330 under the control of Scer\GAL4Lsp2.PH partially rescues the increase in triglyceride levels and the heart defects normally caused by a high-fat diet.

      Expression of CG3523KK107330 under the simultaneous control of both Scer\GAL4Scer\UAS.cHa and Scer\GAL4tin.cBa does not rescue the increase in triglyceride levels caused by a high-fat diet. However, the heart defects normally caused by a high-fat diet are rescued in these animals.

      (Birse et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased triglyceride levels seen in the hearts of 1 week old eas2 females are suppressed if they are also expressing CG3523KK107330 under the control of Scer\GAL4HCH.Hand.

      Expression of CG3523KK107330 under the control of Scer\GAL4HCH.Hand rescues the increased heartbeat rate, constricted heart phenotype and muscle defects of eas2 flies.

      (Lim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG3523KK107330
      FASN1KK107330
      Name Synonyms
      Secondary FlyBase IDs
        References (8)