FlyBase Allele Report: Dmel\UQCR-C1[KK108539]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\UQCR-C1^KK108539

General Information

Symbol

Dmel\UQCR-C1^KK108539

Species

D. melanogaster

Name

FlyBase ID

FBal0235634

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of late onset Parkinson's disease

CEA

(Hung et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(McGurk and Bonini, 2012)

model of late onset Parkinson's disease

is ameliorated by Hsap\UQCRC1^UAS.Tag:V5

(Hung et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | embryonic stage, with Scer\GAL4^srp.Hemo

(Emtenani et al., 2022)

Phenotype Manifest In

embryonic/larval plasmatocyte | embryonic stage, with Scer\GAL4^srp.Hemo

(Emtenani et al., 2022)

germ band, with Scer\GAL4^srp.Hemo

(Emtenani et al., 2022)

yolk, with Scer\GAL4^srp.Hemo

(Emtenani et al., 2022)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

UQCR-C1^KK108539, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

UQCR-C1^KK108539, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v101350

P{KK108539}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG3731^KK108539

UQCR-C1^KK108539

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections