FlyBase Allele Report: Dmel\Hyccin[KK108796]

General Information

Symbol

Dmel\Hyccin^KK108796

Species

D. melanogaster

Name

FlyBase ID

FBal0235826

Feature type

allele

Associated gene

Dmel\Hyccin

Associated Insertion(s)

Carried in Construct

P{KK108796}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108796}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108796

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hypomyelinating leukodystrophy 5

CEA

(Zhang et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Sun et al., 2018)

model of hypomyelinating leukodystrophy 5

is ameliorated by Hsap\HYCC1^UAS.cSa

(Zhang et al., 2022)

is ameliorated by Hsap\HYCC2^UAS.cZa

(Zhang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Hyccin^KK108796 under the control of Scer\GAL4^shot-OK307 do not show significant decreases in lifespan, in climbing ability or in neurotransmission to DM muscles, as compared to controls.

(Sun et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hyccin^KK108796, Scer\GAL4^shot-OK307 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hyccin^KK108796, Scer\GAL4^shot-OK307 is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hyccin^KK108796, Scer\GAL4^shot-OK307 is a suppressor of abnormal neurophysiology | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hyccin^KK108796, Scer\GAL4^shot-OK307 is a suppressor of dorsal longitudinal indirect flight muscle cell phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104577

P{KK108796}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG6406^KK108796

Hyccin^KK108796

hyccin^RNAi

(Zhang et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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