FlyBase Allele Report: Dmel\G6pd[KK108898]

General Information

Symbol

Dmel\G6pd^KK108898

Species

D. melanogaster

Name

FlyBase ID

FBal0235909

Feature type

allele

Associated gene

Dmel\G6pd

Associated Insertion(s)

Carried in Construct

P{KK108898}

Also Known As

UAS-G6PD^RNAi, G6PD RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108898}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108898

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates adult-onset myofibrillar myopathy 2A

modeled by Hsap\CRYAB^R120G.UAS

(Xie et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^VT030559

(de Tredern et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^GMR.PF-driven expression of Zw^KK108898 does not result in detectable eye ablation.

(Yang et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

G6pd^KK108898/Scer\GAL4^da.PU is a non-enhancer of abnormal cell cycle phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Suppressor of

Statement

Reference

G6pd^KK108898/Scer\GAL4^da.PU is a suppressor of abnormal size phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

G6pd^KK108898, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

NOT Suppressor of

Statement

Reference

G6pd^KK108898/Scer\GAL4^da.PU is a non-suppressor of abnormal cell cycle phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

G6pd^KK108898/Scer\GAL4^da.PU is a non-suppressor of neoplasia phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Other

Statement

Reference

G6pd^KK108898, Scer\GAL4^da.PU, brat^HMS01121 has increased cell death phenotype

(Hussain et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

G6pd^KK108898/Scer\GAL4^sns.PU is an enhancer of nephrocyte | larval stage phenotype of Scer\GAL4^sns.PU, dlg1^JF02287

(Xi et al., 2024)

G6pd^KK108898/Scer\GAL4^sns.PU is an enhancer of nephrocyte diaphragm | larval stage phenotype of Scer\GAL4^sns.PU, dlg1^JF02287

(Xi et al., 2024)

Suppressor of

Statement

Reference

G6pd^KK108898, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

Other

Statement

Reference

G6pd^KK108898, Scer\GAL4^da.PU, brat^HMS01121 has larval brain phenotype

(Hussain et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The larval brain overgrowth exhibited upon expression of brat^HMS01121 under the control of Scer\GAL4^da.PU is suppressed when Zw^KK108898 is co-expressed. Co-expression of Zw^KK108898 also leads to a significant increase in cell death. The proportion of defective anaphases seen in larval brains expressing brat^HMS01121 under the control of Scer\GAL4^da.PU is not significantly changed upon co-expression of Zw^KK108898. The tumor growth rate of larval brain explants expressing brat^HMS01121 under the control of Scer\GAL4^da.PU is not suppressed upon co-expression of Zw^KK108898.

(Hussain et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101507

P{KK108898}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

G6pd^KK108898

Zw^KK108898

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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