FlyBase Allele Report: Dmel\levy[KK108963]

General Information

Symbol

Dmel\levy^KK108963

Species

D. melanogaster

Name

FlyBase ID

FBal0235943

Feature type

allele

Associated gene

Dmel\levy

Associated Insertion(s)

Carried in Construct

P{KK108963}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108963}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108963

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^Scer\UAS.cFa

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^UAS.cFa

(Kemppainen et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Scer\GAL4^da.PU

(Kemppainen et al., 2014)

short lived, with Scer\GAL4^da.PU

(Kemppainen et al., 2014)

visible, with Scer\GAL4^da.PU

(Kemppainen et al., 2014)

visible, with Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

Phenotype Manifest In

wing, with Scer\GAL4^da.PU

(Kemppainen et al., 2014)

wing, with Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

Detailed Description

Statement

Reference

Expression of levy^KK108963 driven by Scer\GAL4^da.PU is partially lethal to females at the pupal stage, while male lethality is variable; eclosing flies fail to inflate wings and die in food shortly after eclosion; expression driven by Scer\GAL4^elav-C155 (but not Scer\GAL4^G14) produces the uninflated wing phenotype.

(Kemppainen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^da.PU, levy^KK108963 has partially lethal - majority die phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

Scer\GAL4^elav-C155, levy^KK108963 has visible phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, levy^KK108963 has wing phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Zzzz\AOX^Scer\UAS.cFa partially suppresses female lethality (though flies are still weak) in flies with expression of levy^KK108963 driven by Scer\GAL4^da.PU. Co-expression of Zzzz\AOX^Scer\UAS.cFa partially suppresses the uninflated wing phenotype in flies with expression of levy^KK108963 driven by Scer\GAL4^elav-C155.

(Kemppainen et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101523

P{KK108963}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

levy^KK108963

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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