FlyBase Allele Report: Dmel\Glo1[KK109109]

General Information

Symbol

Dmel\Glo1^KK109109

Species

D. melanogaster

Name

FlyBase ID

FBal0236057

Feature type

allele

Associated gene

Dmel\Glo1

Associated Insertion(s)

Carried in Construct

P{KK109109}

Also Known As

Glo1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109109}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109109

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Vicente Miranda et al., 2017)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Vicente Miranda et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

short lived, with Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Glo1^KK109109 under the control of Scer\GAL4^elav-C155 leads to a significant and progressive decrease in adult locomotor capacity (in negative geotaxis assays), and leads to a small but significant decrease in lifespan, as compared to controls.

(Vicente Miranda et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Glo1^KK109109, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Glo1^KK109109, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Enhancer of

Statement

Reference

Glo1^KK109109, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

NOT Enhancer of

Statement

Reference

Glo1^KK109109, Scer\GAL4^elav-C155 is a non-enhancer of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of Glo1^KK109109 and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 leads to a significant and progressive decrease in adult locomotor capacity (in negative geotaxis assays) and a significant decrease in lifespan, both of which are more severe than either single expression condition.

(Vicente Miranda et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101560

P{KK109109}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG1707^KK109109

Glo1^KK109109

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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