FlyBase Allele Report: Dmel\Gbp1[KK110262]

General Information

Symbol

Dmel\Gbp1^KK110262

Species

D. melanogaster

Name

FlyBase ID

FBal0236741

Feature type

allele

Associated gene

Dmel\Gbp1

Associated Insertion(s)

Carried in Construct

P{KK110262}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK110262}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK110262

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage, with Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

decreased body size | pharate adult stage, with Scer\GAL4^C7

(Koyama and Mirth, 2016)

decreased body size | pharate adult stage, with Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Gbp1^KK110262 expression driven by Scer\GAL4^C7 induces significant decreases in male and female body size (body weight measured at pharate adult stage), but does not significantly affect larval growth rate or the duration of the third instar larval stage.

Gbp1^KK110262 expression driven by Scer\GAL4^ppl.PP induces significant decreases in male and female body size (body weight measured at pharate adult stage) and reduces larval growth rate.

(Koyama and Mirth, 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gbp1^KK110262, Scer\GAL4^C7 has decreased body size | pharate adult stage phenotype, enhanceable by Gbp2^GD4931, Scer\GAL4^C7

(Koyama and Mirth, 2016)

Gbp1^KK110262, Scer\GAL4^ppl.PP has decreased body size | pharate adult stage phenotype, enhanceable by Gbp2^GD4931, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Gbp1^KK110262, Scer\GAL4^ppl.PP has abnormal developmental rate | larval stage phenotype, enhanceable by Gbp2^GD4931, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Enhancer of

Statement

Reference

Gbp1^KK110262, Scer\GAL4^C7 is an enhancer of decreased body size | pharate adult stage phenotype of Gbp2^GD4931, Scer\GAL4^C7

(Koyama and Mirth, 2016)

Gbp1^KK110262, Scer\GAL4^ppl.PP is an enhancer of abnormal developmental rate | larval stage phenotype of Gbp2^GD4931, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Gbp1^KK110262, Scer\GAL4^ppl.PP is an enhancer of decreased body size | pharate adult stage phenotype of Gbp2^GD4931, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Gbp2^GD4931 enhances decreased body size seen in male and female flies with Gbp1^KK110262 driven by Scer\GAL4^C7.

Co-expression of Gbp1^KK110262 enhances the male and female fly decreased body size, along with the decreased larval growth rate and the increase in duration of the third instar stage seen in larvae with Gbp2^GD4931 driven by Scer\GAL4^ppl.PP.

(Koyama and Mirth, 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108755

P{KK110262}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG15917^KK110262

Gbp1^KK110262

Gbp^KK110262

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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