FB2026_02 , released June 18, 2026
Allele: Dmel\FstKK110516
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General Information
Symbol
Dmel\FstKK110516
Species
D. melanogaster
Name
FlyBase ID
FBal0236896
Feature type
allele
Associated gene
Dmel\Fst
Associated Insertion(s)
Carried in Construct
P{KK110516}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK110516}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK110516
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing FstKK110516 under the control of either the Scer\GAL4αTub84B.PL or the Scer\GAL4Act5C.PI driver take longer to recover from cold-induced coma than controls.

      Expression of FstKK110516 under the control of Scer\GAL4αTub84B.PL increases the mortality rate in female flies 24 hours after cold-induced coma. The mortality rate in males is similar to controls. The mortality rate in males and females is increased when FstKK110516 is expressed under the control of the Scer\GAL4Act5C.PI driver.

      Male and female FstKK110516 mutants under the control of the Scer\GAL4Act5C.PI driver are more susceptible to injury following cold induced coma than controls. Injury recovery rate is also impaired compared to controls in both sexes.

      (Colinet et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      FstKK110516
      KK102049
      (Colinet et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)