FlyBase Allele Report: Dmel\Pak3[KK111386]

General Information

Symbol

Dmel\Pak3^KK111386

Species

D. melanogaster

Name

FlyBase ID

FBal0237390

Feature type

allele

Associated gene

Dmel\Pak3

Associated Insertion(s)

Carried in Construct

P{KK111386}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111386}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111386

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates spinocerebellar ataxia 1

modeled by Hsap\ATXN1^82Q.UAS

(Bondar et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

Detailed Description

Statement

Reference

The expression of Pak3^KK111386 under the control of Scer\GAL4^ppk.PG results in a reduced dendritic arborization in third instar larval class IV abdominal dorsal multidendritic ddaC neurons, as compared to controls; expression under the control of Scer\GAL4²²¹ has no obvious effect in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons, as compared to controls.

(Hattori et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107260

P{KK111386}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pak3^KK111386

(Bondar et al., 2018)

Pak3^RNAi-1

(Bondar et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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