FlyBase Allele Report: Dmel\Tom7[KK112286]

General Information

Symbol

Dmel\Tom7^KK112286

Species

D. melanogaster

Name

FlyBase ID

FBal0238027

Feature type

allele

Associated gene

Dmel\Tom7

Associated Insertion(s)

Carried in Construct

P{KK112286}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112286}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112286

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tom7^KK112286/Scer\GAL4^Mhc.PU is an enhancer of visible | adult stage phenotype of Pink1^B9

(Gehrke et al., 2015)

Tom7^KK112286/Scer\GAL4^Mhc.PU is an enhancer of abnormal jumping phenotype of Pink1^B9

(Gehrke et al., 2015)

Tom7^KK112286/Scer\GAL4^ple.PF is an enhancer of abnormal neuroanatomy | adult stage phenotype of Pink1^B9

(Gehrke et al., 2015)

Tom7^KK112286/Scer\GAL4^ple.PF is an enhancer of decreased cell number | adult stage phenotype of Pink1^B9

(Gehrke et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tom7^KK112286/Scer\GAL4^Mhc.PU is an enhancer of wing | adult stage phenotype of Pink1^B9

(Gehrke et al., 2015)

Tom7^KK112286/Scer\GAL4^ple.PF is an enhancer of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Gehrke et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing posture and jumping ability defects as well as the loss of dopaminergic neurons from the PPL1 cluster characteristic for Pink1^B9 adult homozygotes are exacerbated by expression (controlled by either the Scer\GAL4^Mhc.PU muscle driver or the Scer\GAL4^ple.PF neuronal driver) of Tom7^KK112286.

(Gehrke et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102728

P{KK112286}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tom7^KK112286

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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