FlyBase Allele Report: Dmel\Trl[KK112776]

General Information

Symbol

Dmel\Trl^KK112776

Species

D. melanogaster

Name

FlyBase ID

FBal0238394

Feature type

allele

Associated gene

Dmel\Trl

Associated Insertion(s)

Carried in Construct

P{KK112776}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112776}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112776

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless, with Scer\GAL4^Mef2.PR

(Meiler et al., 2021)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

viable, with Scer\GAL4^Mef2.PR

(Meiler et al., 2021)

visible, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

indirect flight muscle cell | pupal stage, with Scer\GAL4^Mef2.PR

(Meiler et al., 2021)

skeletal muscle myofibril | pupal stage, with Scer\GAL4^Mef2.PR

(Meiler et al., 2021)

wing, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

wing, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

The expression of Trl^KK112776 under the control of Scer\GAL4^Mef2.PR induces disordered and frayed myofibrils in pupal indirect flight muscles.

(Meiler et al., 2021)

Expression of Trl^KK112776 results in: slightly rough eye phenotype (with the Scer\GAL4^GMR.PF driver), unfurled wings (with Scer\GAL4^nub.PK) or lethality (with Scer\GAL4^Act5C.PI). Expression controlled by either Scer\GAL4^ey.PH or Scer\GAL4^en.PU has no overt adult phenotype.

(Dietz et al., 2015)

Expression of Trl^KK112776 under the control of Scer\GAL4^Bx-MS1096 results in male flies with almost complete wing loss.

Expression of Trl^KK112776 under the control of Scer\GAL4^Bx-MS1096 results in female flies with almost complete wing loss.

(Schertel et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Trl^KK112776/Scer\GAL4^GMR.PFa is a suppressor of increased occurrence of cell division | larval stage phenotype of Scer\GAL4^GMR.PFa, yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Rader et al., 2023)

Other

Statement

Reference

Scer\GAL4^GMR.PFa, Trl^KK112776, yki^{S111A.S168A.S250A.UAS.Tag:V5} has abnormal cell number | larval stage phenotype

(Rader et al., 2023)

Phenotype Manifest In

Other

Statement

Reference

Scer\GAL4^GMR.PFa, Trl^KK112776, yki^{S111A.S168A.S250A.UAS.Tag:V5} has eye disc | larval stage phenotype

(Rader et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106433

P{KK112776}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Trl^KK112776

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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