FB2026_02 , released June 18, 2026
Allele: Dmel\Su(var)3-7R2a8
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General Information
Symbol
Dmel\Su(var)3-7R2a8
Species
D. melanogaster
Name
FlyBase ID
FBal0239022
Feature type
allele
Associated gene
Dmel\Su(var)3-7
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-in gene targeting
(Spierer et al., 2005)
FLPase
(Spierer et al., 2005)
I-SceI
(Spierer et al., 2005)
I-CreI
(Spierer et al., 2005)
Progenitor genotype
Cytology
Description

Deletion of most of the protein coding sequence of Su(var)3-7 (81 amino acids from the N-terminus remain).

(Spierer et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The progeny of homozygous mutant flies stop developing during the second larval instar. This maternal effect is rescued by a paternal wild-type copy of Su(var)3-7, but only half of the expected male progeny are recovered. Zygotically mutant male and female animals show approximately 90% viability.

      Mutant larvae show an extreme enlargement of the ring gland due to an increase in size of the prothoracic gland cells. The polytene chromosomes of the prothoracic gland cells are more highly endoreplicated than normal.

      (Spierer et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The sumoylation of Su(var)3-7 (at the lysine at position K839) is necessary for heterochromatic localization and the ability to enhance position-effect variegation.

      (Reo et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(var)3-7R2A8
      (Josse et al., 2007)
      Su(var)3-7R2a8
      (Basquin et al., 2014, Reo et al., 2010, Spierer et al., 2008, Johansson et al., 2007, Spierer et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)