FB2021_01, released Feb 18, 2021

Gene: Dmel\Su(var)3-7

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General Information
Symbol
Dmel\Su(var)3-7
Species
D. melanogaster
Name
Suppressor of variegation 3-7
Annotation Symbol
CG8599
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003598
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

Suvar(3)7, Su-var(3)7

Key Links
Genomic Location
Cytogenetic map
87E3-87E3
Sequence location
3R:13,264,364..13,270,038 [+]
Recombination map

3-53

RefSeq locus
NT_033777 REGION:13264364..13270038
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Cleard et al., 1997)
enables protein binding
inferred from physical interaction with FLYBASE:Su(var)205; FB:FBgn0003607
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR004210
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables glycerol-3-phosphate dehydrogenase [NAD+] activity
inferred from biological aspect of ancestor with PANTHER:PTN000919759
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in dosage compensation by hyperactivation of X chromosome
inferred from mutant phenotype
(Spierer et al., 2008)
involved_in positive regulation of heterochromatin assembly
inferred from genetic interaction with FLYBASE:mle; FB:FBgn0002774
(Spierer et al., 2008)
involved_in positive regulation of pericentric heterochromatin assembly
inferred from mutant phenotype
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in glycerol-3-phosphate metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000198006
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in NADH oxidation
inferred from biological aspect of ancestor with PANTHER:PTN000919759
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
located_in nucleus
inferred from direct assay
(Cleard et al., 1997)
located_in pericentric heterochromatin
inferred from direct assay
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000198006
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MADF-BESS DOMAIN TRANSCRIPTION REGULATORS -
The MADF-BESS domain transcription regulators include a variety of activators and corepressors and chromatin modifying proteins. BESS domains are often present in combination with MADF domains. The BESS domain mediates protein-protein interactions. (Adapted from FBrf0155780 and FBrf0224045).
Protein Function (UniProtKB)
Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.
(UniProt, P20193)
Summary (Interactive Fly)

chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting - increasing the amount of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Su(var)3-7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Su(var)3-7-RA
FBtr0082736
NM_079618
5051
1250
Su(var)3-7-RB
FBtr0301657
NM_001170130
4217
1248
Additional Transcript Data and Comments
Reported size (kB)

2.796 (compiled cDNA)

(Reuter et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Su(var)3-7-PA
FBpp0082204
140.0
1250
6.39
NP_524342
AAF54918
Su(var)3-7-PB
FBpp0290871
139.8
1248
6.39
NP_001163601
ACZ94898
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

932 (aa)

(Reuter et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Su(var)39 through the BESS domain.

(UniProt, P20193)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)3-7 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | intense | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
salivary gland
(Jaquet et al., 2006)
salivary gland
(Jaquet et al., 2006)
embryonic stage 5
cell
• nucleus
(Seum et al., 2002)
Additional Descriptive Data
Marker for
 
chromosome, centromeric region
(Jaquet et al., 2006)
Subcellular Localization
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
located_in nucleus
inferred from direct assay
(Cleard et al., 1997)
located_in pericentric heterochromatin
inferred from direct assay
(Cleard et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)3-7 in GBrowse 2
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(var)3-7
Transgenic constructs containing regulatory region of Su(var)3-7
Aberrations (Deficiencies and Duplications) ( 58 )
Inferred from experimentation
Gene disrupted in
Df(3R)615
(McCarron et al., 1994)
Df(3R)2515
(McCarron et al., 1994)
Df(3R)2519
(McCarron et al., 1994)
Df(3R)2520
(McCarron et al., 1994)
Df(3R)2525
(McCarron et al., 1994)
Df(3R)Ace-HD1
(Schotta et al., 2002, Seum et al., 2000)
Df(3R)Exel8158
(Ryder, 2004.4.26)
Df(3R)GE41
(Reuter et al., 1987)
Df(3R)kar-Sz11
(Reuter et al., 1987)
Df(3R)kar-Sz28
(Reuter et al., 1987)
Df(3R)l26c
(Bushey and Locke, 2004)
Df(3R)l26d
(Reuter et al., 1987)
Df(3R)lC4a
(Reuter et al., 1987)
Df(3R)ry27
(Bushey and Locke, 2004)
Df(3R)ry615
(Bushey and Locke, 2004)
Df(3R)Su(var)3-7-P13
(Bushey and Locke, 2004)
Df(3R)Su(var)3-7-P47
(Bushey and Locke, 2004)
Gene duplicated in
Dp(3;3)D7
(Reuter et al., 1987)
Gene not disrupted in
Df(3R)2521
(McCarron et al., 1994)
Df(3R)2522
(McCarron et al., 1994)
Df(3R)2523
(McCarron et al., 1994)
Df(3R)2524
(McCarron et al., 1994)
Df(3R)2526
(McCarron et al., 1994)
Df(3R)2527
(McCarron et al., 1994)
Df(3R)2528
(McCarron et al., 1994)
Df(3R)cu
(Reuter et al., 1987)
Df(3R)E79
(Reuter et al., 1987)
Df(3R)E229
(Reuter et al., 1987)
Df(3R)kar1W
(Reuter et al., 1987)
Df(3R)kar3J
(Reuter et al., 1987)
Df(3R)kar3l
(Reuter et al., 1987)
Df(3R)kar3Q
(Reuter et al., 1987)
Df(3R)kar-D1
(Reuter et al., 1987)
Df(3R)kar-H5
(McCarron et al., 1994)
Df(3R)kar-Sz8
(Reuter et al., 1987)
Df(3R)kar-Sz12
(Reuter et al., 1987)
Df(3R)kar-Sz30
(Reuter et al., 1987)
Df(3R)kar-Sz37
(Reuter et al., 1987)
Df(3R)M-Kx1
(Reuter et al., 1987)
Df(3R)MS-31
(Reuter et al., 1987)
Df(3R)P-10
(Reuter et al., 1987)
Df(3R)P-21
(Reuter et al., 1987)
Df(3R)P-29
(Reuter et al., 1987)
Df(3R)P-35
(Reuter et al., 1987)
Df(3R)P-79
(Reuter et al., 1987)
Df(3R)red3l
(Reuter et al., 1987)
Df(3R)ry614
(Reuter et al., 1987)
Df(3R)ry1402
(Reuter et al., 1987)
Df(3R)ry1607
(Reuter et al., 1987)
Df(3R)T-7
(Reuter et al., 1987)
Df(3R)T-10
(Reuter et al., 1987)
Df(3R)T-32
(Reuter et al., 1987)
Df(3R)T-45
(Reuter et al., 1987)
Gene not duplicated in
Dp(3;3)D1a
(Reuter et al., 1987)
Dp(3;3)D2
(Reuter et al., 1987)
Dp(3;3)D10
(Reuter et al., 1987)
Dp(3;3)D26
(Reuter et al., 1987)
Dp(3;3)D45
(Reuter et al., 1987)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage | recessive | rescuable maternal effect
lethal - all die before end of second instar larval stage | recessive | rescuable maternal effect
lethal - all die during second instar larval stage | maternal effect
lethal - all die during third instar larval stage | maternal effect
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
enhancer of variegation
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried}D
enhancer of variegation, with Dp(1;f)1187
enhancer of variegation, with Dp(3;Y)BL2
enhancer of variegation, with In(1)wm4
enhancer of variegation, with In(1)wm4h
enhancer of variegation, with In(1)wm4h, Scer\GAL4da.G32
enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
enhancer of variegation, with In(2)Heidi-P{Winkelried}D
enhancer of variegation, with P{hsp26-pt-T}39C-12
enhancer of variegation | dominant, with In(1)wm4h
non-enhancer of variegation, with In(1)wm4h, Scer\GAL4da.G32
non-enhancer of variegation, with In(2)Heidi-P{Winkelried}D
non-suppressor of variegation, with In(1)wm4
non-suppressor of variegation, with In(2)Heidi-P{Winkelried}D
some die during larval stage | rescuable maternal effect
some die during second instar larval stage | rescuable maternal effect
suppressor of variegation, with In(1)wm4
suppressor of variegation, with In(1)wm4h
suppressor of variegation, with In(2)Heidi-P{Winkelried}D
suppressor of variegation, with In(2R)bwVDe2
suppressor of variegation, with P{hsp26-pt-T}39C-3
suppressor of variegation, with P{hsp26-pt-T}39C-12
suppressor of variegation, with P{hsp26-pt-T}39C-42
suppressor of variegation, with P{hsp26-pt-T}118E-10
suppressor of variegation, with P{hsp26-pt-T}gw39C-33
suppressor of variegation, with P{hsp26-pt-T}HS-2
suppressor of variegation | dominant, with In(1)wm4h
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5
suppressor of variegation | dominant, with P{hsp26-pt-T}Abcd139C-34
wild-type
Phenotype manifest in
Allele
adult cuticle
humeral bristle
macrochaeta
ommatidium
polytene chromosome | male
polytene chromosome chromocenter
polytene chromosome chromocenter (with Su(var)3-79)
polytene chromosome chromocenter (with Su(var)3-714)
prothoracic gland
sex comb
tergite
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GPD1
1 of 15
Yes
No
1  
Hsap\GPD1L
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gpd1l
1 of 15
Yes
No
Mmus\Gpd1
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
Rnor\Gpd1l
1 of 13
Yes
No
Rnor\Gpd1
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\gpd1l
1 of 12
Yes
No
Xtro\gpd1
1 of 12
Yes
No
Danio rerio (Zebrafish) (4)
Drer\gpd1a
1 of 15
Yes
No
Drer\gpd1b
1 of 15
Yes
No
Drer\gpd1c
1 of 15
Yes
No
Drer\gpd1l
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\gpdh-1
1 of 15
Yes
No
Cele\gpdh-2
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (1)
Atha\GPDHp
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\GPD1
1 of 15
Yes
No
Scer\GPD2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\gpd1
1 of 12
Yes
No
Spom\gpd2
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901DO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009636
Drosophila simulans
Dsim\GD18892
Drosophila sechellia
Dsec\GM24093
Drosophila erecta
Dere\GG19522
Drosophila yakuba
Dyak\GE26256
Drosophila ananassae
Dana\GF17587
Drosophila pseudoobscura pseudoobscura
Dpse\GA26601
Drosophila persimilis
Dper\GL24399
Drosophila willistoni
Dwil\GK22413
Drosophila virilis
Dvir\Su(var)3-7
Drosophila mojavensis
Dmoj\GI24326
Drosophila grimshawi
Dgri\GH18425
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500YX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025046
Glossina morsitans
Tsetse fly
Gmor\GMOY009295
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11725
Mayetiola destructor
Hessian fly
Mdes\Mdes014827
Mayetiola destructor
Hessian fly
Mdes\Mdes015245
Mayetiola destructor
Hessian fly
Mdes\Mdes015923
Mayetiola destructor
Hessian fly
Mdes\Mdes012691
Mayetiola destructor
Hessian fly
Mdes\Mdes014594
Mayetiola destructor
Hessian fly
Mdes\Mdes009419
Mayetiola destructor
Hessian fly
Mdes\Mdes013823
Mayetiola destructor
Hessian fly
Mdes\Mdes016660
Mayetiola destructor
Hessian fly
Mdes\Mdes014872
Mayetiola destructor
Hessian fly
Mdes\Mdes012208
Mayetiola destructor
Hessian fly
Mdes\Mdes015584
Mayetiola destructor
Hessian fly
Mdes\Mdes003103
Mayetiola destructor
Hessian fly
Mdes\Mdes016200
Mayetiola destructor
Hessian fly
Mdes\Mdes015950
Mayetiola destructor
Hessian fly
Mdes\Mdes013242
Mayetiola destructor
Hessian fly
Mdes\Mdes013168
Anopheles gambiae
Malaria mosquito
Agam\AGAP004826
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016422
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014825
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08HY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG035527
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG024722
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG027074
Tribolium castaneum
Red flour beetle
Tcas\TC009048
Tribolium castaneum
Red flour beetle
Tcas\TC031971
Tribolium castaneum
Red flour beetle
Tcas\TC031653
Rhodnius prolixus
Kissing bug
Rpro\RPRC006584
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI24121
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI39188
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088918
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI32782
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI34043
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI34834
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI062288
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI56184
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069153
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI22727
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI36935
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23176
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI081918
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI52564
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086439
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI21059
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069791
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI53103
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23849
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI26821
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068672
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI35435
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI52188
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086777
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI54763
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085731
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23839
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI082582
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44270
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080741
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001048
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI46585
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI064523
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI064408
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI071576
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085370
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI087230
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI21243
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI28991
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI34133
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI067321
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI54149
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04544
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09413
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D12 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_014958gn
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG34149
2 of 10
Gpdh1
1 of 10
Gpdh2
1 of 10
Gpdh3
1 of 10
Ravus
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Su(var)3-7 - Su(var)205
    anti bait coimmunoprecipitation, western blot, two hybrid
    (Delattre et al., 2000, Cleard et al., 1997)
    Su(var)3-7 - Su(var)3-9
    two hybrid
    (Schotta et al., 2002)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Su(var)3-7
    suppressible
    mle
    (Spierer et al., 2005)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ct|lncRNA:flam
    suppressible
    Su(var)3-7
    (Guida et al., 2016)
    mle
    suppressible
    Su(var)3-7
    (Spierer et al., 2008)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Su(var)39 through the BESS domain.
    (UniProt, P20193 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-53

    Cytogenetic map
    87E3-87E3
    Sequence location
    3R:13,264,364..13,270,038 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87E3-87E3
    Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    87E4-87E5
    (determined by in situ hybridisation)
    (Wustmann et al., 1989)
    87E-87E
    (determined by in situ hybridisation)
    (Reuter et al., 1987)
    Location based on deficiency mapping.
    (Wustmann et al., 1989)
    Experimentally Determined Recombination Data
    Location

    3-53

    (FlyBase, 2016)

    3-50.8

    (Comeron et al., 2012)

    3-50.9

    (Bushey and Locke, 2004)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (23)
    cDNA Clones (59)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Riddle et al., 2012)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments

    Complements all lethals in the region except Acej41; Acej41 has a weak dominant variegation suppression effect.

    Other Comments

    DNA-protein interactions: genome-wide binding profile assayed for Su(var)3-7 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

    (Filion et al., 2010)

    The genomic organisation and pattern of expression of the Su(var)3-7 locus have been characterised.

    (Cleard et al., 1995)

    Phenotype of wbl is unchanged by Su(var)3-7.

    (Csink et al., 1994)

    Su(var)3-7 is a haplo suppressor and a triplo enhancer. The suppressor effect of Su(var)3-9 cannot dominate the enhancer effect displayed by two extra doses of Su(var)3-7.

    (Tschiersch et al., 1994)

    Deletion of one wild type copy of Su(var)3-7 reduces In(1)wm4 position effect variegation and duplication of Su(var)3-7 enhances variegation. A 6.5kb EcoRV gene fragment from Su(var)3-7 is capable of enhancing variegation in a dose-dependent manner.

    (Reuter et al., 1990)

    Duplications of Su(var)3-7 were found to considerably reduce the haplo-abnormal effect of heterozygous Su(var)3-7 point mutations.

    (Reuter et al., 1987)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 31 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (13)
    Reported As
    Symbol Synonym
    CG8599
    (Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009)
    DmSu(var)3-7
    (Jaquet et al., 2006)
    SU(VAR)3-7
    (Ho et al., 2014, Riddle et al., 2012, Demakov et al., 2011, Filion et al., 2010, van Steensel et al., 2010, Pindyurin et al., 2008, Spierer et al., 2008, Andreyeva et al., 2007, Demakova et al., 2007, Grewal and Elgin, 2007, Ronsseray et al., 2007, Ronsseray et al., 2007, Straub and Becker, 2007, Andreyeva et al., 2005, Perrini et al., 2004, Grade et al., 2002, Li et al., 2002, Schotta et al., 2001)
    Su(Var)3-7
    (Nie et al., 2009, Shevelyov et al., 2009)
    Su(var)(3)3
    (Pirrotta, 1990)
    Su(var)(3)7
    (Karpen, 1994)
    Su(var)3-7
    (Kochanova et al., 2020, Parey and Crombach, 2019, Park et al., 2019, Deshpande and Meller, 2018, Transgenic RNAi Project members, 2017-, Guida et al., 2016, Gallach, 2015, Izutsu et al., 2015, Kwong et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Basquin et al., 2014, Comoglio and Paro, 2014, Elgin and Reuter, 2013, Thomae et al., 2013, Feller et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sakoparnig et al., 2012, Abramov et al., 2011, Baig et al., 2010, Deng et al., 2010, Kallappagoudar et al., 2010, Prabhakaran and Kelley, 2010, Reo et al., 2010, Menon and Meller, 2009, de Wit et al., 2008, Doheny et al., 2008, Nisha et al., 2008, Ronsseray et al., 2008, Spierer et al., 2008, Bayes and Malik, 2007, Haynes et al., 2007, Johansson et al., 2007, Josse et al., 2007, Minidorff et al., 2007, Lam et al., 2005, Spierer et al., 2005, Bazin et al., 2004, Delattre et al., 2004, Balasov, 2002, Cleard and Spierer, 2001)
    Su-var(3)7
    (Balasov and Makunin, 1996, Wustmann et al., 1989, Reuter et al., 1987, Reuter et al., 1986)
    Suv3-7
    (Tsai et al., 2016)
    Suvar(3)7
    (Reuter, 1998.12.3, Henikoff, 1996, Cleard et al., 1995, Chan et al., 1994, Peterson and Sapienza, 1993, Reuter and Spierer, 1992, Spierer et al., 1992, Elgin, 1990, Pardue and Hennig, 1990, Paro, 1990, Reuter et al., 1990, Spradling and Karpen, 1990)
    Suvar37
    (Rennie et al., 2018)
    l(3)87El
    Name Synonyms
    Suppressor of variegation 3-7
    (Comoglio and Paro, 2014, Baig et al., 2010)
    Secondary FlyBase IDs
      Datasets (3)
      Study focus (3)
      Experimental Role
      Project
      Project Type
      Title
      • transgene_used
      FBGSE22069
      Protein profiling reveals five principal chromatin types in Drosophila cells.
      • bait_protein
      modENCODE_chromatin_proteins_cells
      Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
      • bait_protein
      modENCODE_chromatin_proteins_flies
      Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
      References (154)