FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Su(var)3-7
Open Close
General Information
Symbol
Dmel\Su(var)3-7
Species
D. melanogaster
Name
Suppressor of variegation 3-7
Annotation Symbol
CG8599
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003598
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Suvar(3)7, Su-var(3)7

Key Links
Genomic Location
Cytogenetic map
87E3-87E3
Sequence location
Recombination map
3-53
RefSeq locus
NT_033777 REGION:13264364..13270038
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Cleard et al., 1997)
enables protein binding
inferred from physical interaction with FLYBASE:Su(var)205; FB:FBgn0003607
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR004210
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in dosage compensation by hyperactivation of X chromosome
inferred from mutant phenotype
(Spierer et al., 2008)
involved_in positive regulation of heterochromatin formation
inferred from genetic interaction with FLYBASE:mle; FB:FBgn0002774
(Spierer et al., 2008)
involved_in positive regulation of pericentric heterochromatin formation
inferred from mutant phenotype
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
located_in nucleus
inferred from direct assay
(Cleard et al., 1997)
located_in pericentric heterochromatin
inferred from direct assay
(Cleard et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001940778
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
MADF-BESS DOMAIN TRANSCRIPTION REGULATORS -
The MADF-BESS domain transcription regulators include a variety of activators and corepressors and chromatin modifying proteins. BESS domains are often present in combination with MADF domains. The BESS domain mediates protein-protein interactions. (Adapted from FBrf0155780 and FBrf0224045).
Protein Function (UniProtKB)
Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.
(UniProt, P20193)
Summary (Interactive Fly)

chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting - increasing the amount of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Su(var)3-7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P20193)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Su(var)3-7-RA
FBtr0082736
NM_079618
5051
1250
Su(var)3-7-RB
FBtr0301657
NM_001170130
4217
1248
Additional Transcript Data and Comments
Reported size (kB)

2.796 (compiled cDNA)

(Reuter et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Su(var)3-7-PA
FBpp0082204
140.0
1250
6.39
P20193
NP_524342
AAF54918
Su(var)3-7-PB
FBpp0290871
139.8
1248
6.39
E1JIJ9
NP_001163601
ACZ94898
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

932 (aa)

(Reuter et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Su(var)39 through the BESS domain.

(UniProt, P20193)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)3-7 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.30

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | intense | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
cell
• nucleus
(Seum et al., 2002)
third instar larval stage
salivary gland
(Jaquet et al., 2006)
salivary gland
(Jaquet et al., 2006)
Additional Descriptive Data
Marker for
 
chromosome, centromeric region
(Jaquet et al., 2006)
Subcellular Localization
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
located_in nucleus
inferred from direct assay
(Cleard et al., 1997)
located_in pericentric heterochromatin
inferred from direct assay
(Cleard et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)3-7 in JBrowse
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 38 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(var)3-7
Transgenic constructs containing regulatory region of Su(var)3-7
Aberrations (Deficiencies and Duplications) ( 58 )
Inferred from experimentation ( 58 )
Gene disrupted in
Df(3R)615
(McCarron et al., 1994)
Df(3R)2515
(McCarron et al., 1994)
Df(3R)2519
(McCarron et al., 1994)
Df(3R)2520
(McCarron et al., 1994)
Df(3R)2525
(McCarron et al., 1994)
Df(3R)Ace-HD1
(Schotta et al., 2002, Seum et al., 2000)
Df(3R)Exel8158
(Ryder, 2004.4.26)
Df(3R)GE41
(Reuter et al., 1987)
Df(3R)kar-Sz11
(Reuter et al., 1987)
Df(3R)kar-Sz28
(Reuter et al., 1987)
Df(3R)l26c
(Bushey and Locke, 2004)
Df(3R)l26d
(Reuter et al., 1987)
Df(3R)lC4a
(Reuter et al., 1987)
Df(3R)ry27
(Bushey and Locke, 2004)
Df(3R)ry615
(Bushey and Locke, 2004)
Df(3R)Su(var)3-7-P13
(Bushey and Locke, 2004)
Df(3R)Su(var)3-7-P47
(Bushey and Locke, 2004)
Gene duplicated in
Dp(3;3)D7
(Reuter et al., 1987)
Gene not disrupted in
Df(3R)2521
(McCarron et al., 1994)
Df(3R)2522
(McCarron et al., 1994)
Df(3R)2523
(McCarron et al., 1994)
Df(3R)2524
(McCarron et al., 1994)
Df(3R)2526
(McCarron et al., 1994)
Df(3R)2527
(McCarron et al., 1994)
Df(3R)2528
(McCarron et al., 1994)
Df(3R)cu
(Reuter et al., 1987)
Df(3R)E79
(Reuter et al., 1987)
Df(3R)E229
(Reuter et al., 1987)
Df(3R)kar1W
(Reuter et al., 1987)
Df(3R)kar3J
(Reuter et al., 1987)
Df(3R)kar3l
(Reuter et al., 1987)
Df(3R)kar3Q
(Reuter et al., 1987)
Df(3R)kar-D1
(Reuter et al., 1987)
Df(3R)kar-H5
(McCarron et al., 1994)
Df(3R)kar-Sz8
(Reuter et al., 1987)
Df(3R)kar-Sz12
(Reuter et al., 1987)
Df(3R)kar-Sz30
(Reuter et al., 1987)
Df(3R)kar-Sz37
(Reuter et al., 1987)
Df(3R)M-Kx1
(Reuter et al., 1987)
Df(3R)MS-31
(Reuter et al., 1987)
Df(3R)P-10
(Reuter et al., 1987)
Df(3R)P-21
(Reuter et al., 1987)
Df(3R)P-29
(Reuter et al., 1987)
Df(3R)P-35
(Reuter et al., 1987)
Df(3R)P-79
(Reuter et al., 1987)
Df(3R)red3l
(Reuter et al., 1987)
Df(3R)ry614
(Reuter et al., 1987)
Df(3R)ry1402
(Reuter et al., 1987)
Df(3R)ry1607
(Reuter et al., 1987)
Df(3R)T-7
(Reuter et al., 1987)
Df(3R)T-10
(Reuter et al., 1987)
Df(3R)T-32
(Reuter et al., 1987)
Df(3R)T-45
(Reuter et al., 1987)
Gene not duplicated in
Dp(3;3)D1a
(Reuter et al., 1987)
Dp(3;3)D2
(Reuter et al., 1987)
Dp(3;3)D10
(Reuter et al., 1987)
Dp(3;3)D26
(Reuter et al., 1987)
Dp(3;3)D45
(Reuter et al., 1987)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage | recessive | rescuable maternal effect
lethal - all die before end of second instar larval stage | recessive | rescuable maternal effect
lethal - all die during second instar larval stage | maternal effect
lethal - all die during third instar larval stage | maternal effect
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
enhancer of variegation
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried}D
enhancer of variegation, with Dp(1;f)1187
enhancer of variegation, with Dp(3;Y)BL2
enhancer of variegation, with In(1)wm4
enhancer of variegation, with In(1)wm4h
enhancer of variegation, with In(1)wm4h, Scer\GAL4da.G32
enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
enhancer of variegation, with In(2)Heidi-P{Winkelried}D
enhancer of variegation, with P{hsp26-pt-T}39C-12
enhancer of variegation | dominant, with In(1)wm4h
non-enhancer of variegation, with In(1)wm4h, Scer\GAL4da.G32
non-enhancer of variegation, with In(2)Heidi-P{Winkelried}D
non-suppressor of variegation, with In(1)wm4
non-suppressor of variegation, with In(2)Heidi-P{Winkelried}D
some die during larval stage | rescuable maternal effect
some die during second instar larval stage | rescuable maternal effect
suppressor of variegation, with In(1)wm4
suppressor of variegation, with In(1)wm4h
suppressor of variegation, with In(2)Heidi-P{Winkelried}D
suppressor of variegation, with In(2R)bwVDe2
suppressor of variegation, with P{hsp26-pt-T}39C-3
suppressor of variegation, with P{hsp26-pt-T}39C-12
suppressor of variegation, with P{hsp26-pt-T}39C-42
suppressor of variegation, with P{hsp26-pt-T}118E-10
suppressor of variegation, with P{hsp26-pt-T}gw39C-33
suppressor of variegation, with P{hsp26-pt-T}HS-2
suppressor of variegation | dominant, with In(1)wm4h
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5
suppressor of variegation | dominant, with P{hsp26-pt-T}Abcd139C-34
wild-type
Phenotype manifest in
Allele
abdominal tergite
adult cuticle
humeral bristle
macrochaeta
ommatidium
polytene chromosome | male
polytene chromosome chromocenter
polytene chromosome chromocenter (with Su(var)3-79)
polytene chromosome chromocenter (with Su(var)3-714)
prothoracic gland
sex comb
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (0)
Arabidopsis thaliana (thale-cress) (1)
Atha\GLY1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (1)
Ecol\gpsA
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Su(var)3-7. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG34149
3 of 13
Ravus
2 of 13
CG43342
1 of 13
Gpdh1
1 of 13
Gpdh2
1 of 13
Gpdh3
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Su(var)3-7
    suppressible
    mle
    (Spierer et al., 2005)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ct|lncRNA:flam
    suppressible
    Su(var)3-7
    (Guida et al., 2016)
    mle
    suppressible
    Su(var)3-7
    (Spierer et al., 2008)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Su(var)39 through the BESS domain.
    (UniProt, P20193 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-53
    Cytogenetic map
    87E3-87E3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87E3-87E3
    Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    87E4-87E5
    (determined by in situ hybridisation)
    (Wustmann et al., 1989)
    87E-87E
    (determined by in situ hybridisation)
    (Reuter et al., 1987)
    Location based on deficiency mapping.
    (Wustmann et al., 1989)
    Experimentally Determined Recombination Data
    Location

    3-53

    (FlyBase, 2016)

    3-50.8

    (Comeron et al., 2012)

    3-50.9

    (Bushey and Locke, 2004)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (23)
    cDNA Clones (57)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Riddle et al., 2012)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        DNA-protein interactions: genome-wide binding profile assayed for Su(var)3-7 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

        (Filion et al., 2010)

        The genomic organisation and pattern of expression of the Su(var)3-7 locus have been characterised.

        (Cleard et al., 1995)

        Phenotype of wbl is unchanged by Su(var)3-7.

        (Csink et al., 1994)

        Su(var)3-7 is a haplo suppressor and a triplo enhancer. The suppressor effect of Su(var)3-9 cannot dominate the enhancer effect displayed by two extra doses of Su(var)3-7.

        (Tschiersch et al., 1994)

        Deletion of one wild type copy of Su(var)3-7 reduces In(1)wm4 position effect variegation and duplication of Su(var)3-7 enhances variegation. A 6.5kb EcoRV gene fragment from Su(var)3-7 is capable of enhancing variegation in a dose-dependent manner.

        (Reuter et al., 1990)

        Duplications of Su(var)3-7 were found to considerably reduce the haplo-abnormal effect of heterozygous Su(var)3-7 point mutations.

        (Reuter et al., 1987)
        Relationship to Other Genes
        Source for database merge of
        Additional comments

        Complements all lethals in the region except Acej41; Acej41 has a weak dominant variegation suppression effect.

        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (13)
        Reported As
        Symbol Synonym
        CG8599
        (Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009)
        DmSu(var)3-7
        (Jaquet et al., 2006)
        SU(VAR)3-7
        (Ho et al., 2014, Riddle et al., 2012, Demakov et al., 2011, Filion et al., 2010, van Steensel et al., 2010, Pindyurin et al., 2008, Spierer et al., 2008, Andreyeva et al., 2007, Demakova et al., 2007, Grewal and Elgin, 2007, Ronsseray et al., 2007, Ronsseray et al., 2007, Straub and Becker, 2007, Andreyeva et al., 2005, Perrini et al., 2004, Grade et al., 2002, Li et al., 2002, Schotta et al., 2001)
        Su(Var)3-7
        (Nie et al., 2009, Shevelyov et al., 2009)
        Su(var)(3)3
        (Pirrotta, 1990)
        Su(var)(3)7
        (Karpen, 1994)
        Su(var)3-7
        (Jayakrishnan et al., 2025, Jayakrishnan et al., 2024, Makki and Meller, 2024, Petrosky et al., 2024, Zhimulev et al., 2024, Makki and Meller, 2021, Kochanova et al., 2020, Meyer-Nava et al., 2020, Port et al., 2020, Parey and Crombach, 2019, Park et al., 2019, Deshpande and Meller, 2018, Transgenic RNAi Project members, 2017-, Abramov et al., 2016, Guida et al., 2016, Gallach, 2015, Izutsu et al., 2015, Kwong et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Basquin et al., 2014, Comoglio and Paro, 2014, Elgin and Reuter, 2013, Thomae et al., 2013, Feller et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sakoparnig et al., 2012, Abramov et al., 2011, Baig et al., 2010, Deng et al., 2010, Kallappagoudar et al., 2010, Prabhakaran and Kelley, 2010, Reo et al., 2010, Menon and Meller, 2009, de Wit et al., 2008, Doheny et al., 2008, Nisha et al., 2008, Ronsseray et al., 2008, Spierer et al., 2008, Bayes and Malik, 2007, Haynes et al., 2007, Johansson et al., 2007, Josse et al., 2007, Minidorff et al., 2007, Lam et al., 2005, Spierer et al., 2005, Bazin et al., 2004, Delattre et al., 2004, Balasov, 2002, Cleard and Spierer, 2001)
        Su-var(3)7
        (Balasov and Makunin, 1996, Wustmann et al., 1989, Reuter et al., 1987, Reuter et al., 1986)
        Suv3-7
        (Tsai et al., 2016)
        Suvar(3)7
        (Reuter, 1998.12.3, Henikoff, 1996, Cleard et al., 1995, Chan et al., 1994, Peterson and Sapienza, 1993, Reuter and Spierer, 1992, Spierer et al., 1992, Elgin, 1990, Pardue and Hennig, 1990, Paro, 1990, Reuter et al., 1990, Spradling and Karpen, 1990)
        Suvar37
        (Rennie et al., 2018)
        l(3)87El
        Name Synonyms
        Suppressor of variegation 3-7
        (Comoglio and Paro, 2014, Baig et al., 2010)
        Secondary FlyBase IDs
          Datasets (3)
          Study focus (3)
          Experimental Role
          Project
          Project Type
          Title
          • transgene_used
          FBGSE22069
          Protein profiling reveals five principal chromatin types in Drosophila cells.
          • bait_protein
          modENCODE_chromatin_proteins_cells
          Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
          • bait_protein
          modENCODE_chromatin_proteins_flies
          Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 35 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (169)