Suvar(3)7, Su-var(3)7
chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting - increasing the amount of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing.
Please see the JBrowse view of Dmel\Su(var)3-7 for information on other features
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Gene model reviewed during 5.47
2.796 (compiled cDNA)
None of the polypeptides share 100% sequence identity.
932 (aa)
Interacts with Su(var)39 through the BESS domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)3-7 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
GBrowse - Visual display of RNA-Seq signals
View Dmel\Su(var)3-7 in GBrowse 23-53
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
DNA-protein interactions: genome-wide binding profile assayed for Su(var)3-7 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
The genomic organisation and pattern of expression of the Su(var)3-7 locus have been characterised.
Phenotype of wbl is unchanged by Su(var)3-7.
Su(var)3-7 is a haplo suppressor and a triplo enhancer. The suppressor effect of Su(var)3-9 cannot dominate the enhancer effect displayed by two extra doses of Su(var)3-7.
Deletion of one wild type copy of Su(var)3-7 reduces In(1)wm4 position effect variegation and duplication of Su(var)3-7 enhances variegation. A 6.5kb EcoRV gene fragment from Su(var)3-7 is capable of enhancing variegation in a dose-dependent manner.
Duplications of Su(var)3-7 were found to considerably reduce the haplo-abnormal effect of heterozygous Su(var)3-7 point mutations.