FlyBase Allele Report: Dmel\Su(var)3-7[9]

General Information

Symbol

Dmel\Su(var)3-7⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0304389

Feature type

allele

Associated gene

Dmel\Su(var)3-7

Associated Insertion(s)

TI{TI}Su(var)3-7⁹

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-in gene targeting

(Seum et al., 2002)

FLPase

(Seum et al., 2002)

I-SceI

(Seum et al., 2002)

Progenitor genotype

Associated Insertion(s)

TI{TI}Su(var)3-7⁹

Cytology

Description

Duplication at the Su(var)3-7 locus, with each copy of the gene separated by a y⁺²⁰⁸³ marker. The 5' copy contains stop codons at positions 830 and 2240. It is fused at its C-terminus in frame with 157 amino acids of the y protein (this structure is due to the cloning procedure used to make the donor construct). The 3' copy contains a stop codon at position 830.

(Seum et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Seum et al., 2002)

suppressor of variegation, with In(2)Heidi-P{Winkelried}D

(Seum et al., 2002)

suppressor of variegation, with In(2R)bw^VDe2

(Seum et al., 2002)

viable

(Seum et al., 2002)

Phenotype Manifest In

abdominal tergite

(Seum et al., 2002)

adult cuticle

(Seum et al., 2002)

humeral bristle

(Seum et al., 2002)

macrochaeta

(Seum et al., 2002)

ommatidium

(Seum et al., 2002)

polytene chromosome chromocenter (with Su(var)3-7¹⁴)

(Spierer et al., 2005)

sex comb

(Seum et al., 2002)

wing

(Seum et al., 2002)

Detailed Description

Statement

Reference

The chromocenter has loose morphology in polytene chromosome squashes from Dp(3;3)Su(var)3-7¹⁴/Dp(3;3)Su(var)3-7⁹ third instar larvae.

(Spierer et al., 2005)

Homozygous Dp(3;3)Su(var)3-7⁹ mutant adults are viable and fertile. The adults flies display many abnormalities. The most frequent and striking phenotype is an abnormal abdominal cuticle, where the anterior and posterior margins of the tergites are irregularly edged out. Alos, many bristles are disorganised or missing. Other parts of the body also show abnormalities, though less frequently: thinner thoracic macrochaetae, missing humeral and sex comb bristles, spots of irregular ommatidia, and curled or ill developed wings.

Homozygous Su(var)3-7⁹ mutant adults are viable and fertile. The adults flies display many abnormalities. The most frequent and striking phenotype is an abnormal abdominal cuticle, where the anterior and posterior margins of the tergites are irregularly edged out. Also, many bristles are disorganised or missing. Other parts of the body also show abnormalities, though less frequently: thinner thoracic macrochaetae, missing humeral and sex comb bristles, spots of irregular ommatidia, and curled or ill developed wings.

(Seum et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

P{P-Sal}Pak3^P-Sal, P{lacW}Dplac, Su(var)3-7⁹ has suppressor of variegation phenotype

(Bushey and Locke, 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The chromocenter has loose morphology in polytene chromosome squashes from Su(var)3-7¹⁴/Su(var)3-7⁹ third instar larvae.

(Spierer et al., 2005)

When P{P-Sal}Pak3^P-Sal is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w[-] background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Su(var)3-7⁹.

When P{P-Sal}89D is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w^- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Dp(3;3)Su(var)3-7⁹.

(Bushey and Locke, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dp(3;3)Su(var)3-7⁹

Su(var)3-7^9.3'

Su(var)3-7^9.5'

Su(var)3-7⁹

(Basquin et al., 2014, Spierer et al., 2008, Spierer et al., 2005, Bushey and Locke, 2004, Seum et al., 2002)

Name Synonyms

Secondary FlyBase IDs

FBal0147393
FBal0147392
FBab0037619

References (5)

Report Sections

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