FlyBase Allele Report: Dmel\Smr[G0060]

(Heck et al., 2012, Cook, 2009.8.19, Schäfer, 2003.12.4, Peter et al., 2002, Schäfer et al., 1999.6.15, Schäfer et al., 1999.8.12, FlyBase, 1992-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Heck et al., 2012, Cook, 2009.8.19, Schäfer, 2003.12.4)

lethal (with Smr^BG01648)

(Heck et al., 2012)

lethal (with Smr^G0124)

(Heck et al., 2012)

lethal (with Smr^G0361)

(Heck et al., 2012)

lethal (with Smr^PL6)

(Heck et al., 2012)

lethal | recessive

(Schäfer et al., 1999.6.15, Schäfer et al., 1999.8.12)

visible | somatic clone

(Heck et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous females and hemizygous males are lethal.

Homozygous clones induced using Scer\GAL4^T155 result in female with downwardly folded wings with defective wing margins, severely deformed third legs and ectopic and defective bristle formation in the scutellum.

Females containing homozygous clones induced using Scer\GAL4^T155 produce fewer eggs than normal. Embryos derived from eggs laid by these females have severe defects including scarred egg shells and shortened dorsal appendages.

Homozygous follicle cells in mosaic egg chambers are on average larger and contain approximately 1.6-fold more DNA than neighbouring heterozygous cells.

(Heck et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Smr^G0124

(Heck et al., 2012)

Smr^G0361

(Heck et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

5596

Dp(1;Y)BSC1, y⁺/w^67c23 P{lacW}IntS6^G0060 P{lacW}Smr^G0060/C(1)RA, y¹

5794

Dp(1;Y)BSC2, y⁺/w^67c23 P{lacW}IntS6^G0060 P{lacW}Smr^G0060/C(1)RA, y¹

5795

Dp(1;Y)BSC4, y⁺/w^67c23 P{lacW}IntS6^G0060 P{lacW}Smr^G0060/C(1)RA, y¹

5796

Dp(1;Y)BSC5, y⁺/w^67c23 P{lacW}IntS6^G0060 P{lacW}Smr^G0060/C(1)RA, y¹

67127

y¹ w^* Usp7^B P{neoFRT}19A/Dp(1;Y)BSC1, y⁺ w^67c23 P{lacW}Smr^G0060/C(1)RA, y¹

Notes on Origin

Discoverer

Molecular and genetic evidence suggests that there are most likely two P{lacW} insertions on the "G0060" chromosome. The flanking sequence for the line maps to 5B6 (within CG3125) and is represented by the P{lacW}CG3125^G0060 insertion. The lethality of the chromosome maps to the 11C3-4;11D3-8 region and is represented by the P{lacW}l(1)G0060^G0060 insertion.

(Cook, 2009.8.19)

Separable from: CG3125^G0060.

(Cook, 2009.8.19)

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.6.15, Schäfer et al., 1999.8.12)

Precise excision of the insertion reverts the lethal phenotype.

(Heck et al., 2012)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Smr1

(Heck et al., 2012)

Smr¹

(McLean and Cooley, 2013, McLean and Cooley, 2013)

Smr^G0060

l(1)G0060

(Schäfer, 2003.12.4, Peter et al., 2002)

l(1)G0060^G0060

(Popodi et al., 2010-, Cook et al., 2009.11.25, FlyBase, 1992-)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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