FB2026_02 , released June 18, 2026
Allele: Dmel\HtrA2HM05030
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General Information
Symbol
Dmel\HtrA2HM05030
Species
D. melanogaster
Name
FlyBase ID
FBal0239362
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{TRiP.HM05030}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.HM05030}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HM05030
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease 1
      modeled by Hsap\SNCAUAS.cFa
      (Chung et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/HtrA2HM05030 is a suppressor of abnormal neuroanatomy | progressive phenotype of YME1Ldel

      (Qi et al., 2016)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/HtrA2HM05030 is a suppressor of rhabdomere | progressive phenotype of YME1Ldel

      (Qi et al., 2016)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PR/HtrA2HM05030 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      Scer\GAL4Mef2.PR/HtrA2HM05030 is a non-suppressor of flight muscle cell | adult stage phenotype of Pink1B9

      (Ham et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      HtrA2HM05030 suppresses the age-dependent locomotor defect and loss of rhabdomeres seen in YME1Ldel homozygotes.

      (Qi et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HtrA2HM05030
      dOmiIR
      (Qi et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)