FB2025_04 , released October 2, 2025
Allele: Dmel\bratHM05078
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General Information
Symbol
Dmel\bratHM05078
Species
D. melanogaster
Name
FlyBase ID
FBal0239408
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
P{TRiP.HM05078}
Also Known As
UAS-brat RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.HM05078}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HM05078
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of bratHM05078 under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) leads to small and blistered wings, as compared to controls.

      (Hevia et al., 2017)

      Expression of bratHM05078 under the control of Scer\GAL4insc-Mz1407 leads to overproliferation of type-II neuroblast like cells on the dorsal side of larval brains. No obvious defects are seen in type I neuroblast lineages in the ventral nerve cord.

      (Zhu et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of bratHM05078 (together with Dicer-2, for efficient RNAi) partially suppresses the oversized wing defects induced by the expression of SmoxSDVD.Scer\UAS under the control of Scer\GAL4nub.PU.

      (Hevia et al., 2017)

      Co-expression of pntScer\UAS.P1.cZa and bratHM05078 in the type I neuroblasts of the ventral nerve cord using Scer\GAL4insc-Mz1407 results in overproliferation of type II neuroblast-like cells.

      (Zhu et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      bratHM05078
      Name Synonyms
      Secondary FlyBase IDs
        References (8)