FB2026_02 , released June 18, 2026
Allele: Dmel\miltJF03022
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General Information
Symbol
Dmel\miltJF03022
Species
D. melanogaster
Name
FlyBase ID
FBal0239523
Feature type
allele
Associated gene
Dmel\milt
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03022}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF03022}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF03022
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Iijima-Ando et al., 2012)
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Liu et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing miltJF03022 under the control of Scer\GAL4Cg.PA leads to fragmented mitochondria in the third instar larval fat body (as assessed by MitoGFP).

      (Zhou et al., 2019)

      Expression of miltJF03022 in eyes under the control of Scer\GAL4GMR.PF results in loss of mitochondria in the synaptic terminals of the photoreceptor neurons. Flies expressing miltJF03022 under the control of Scer\GAL4GMR.PF alone show age-dependent degeneration in the lamina.

      (Iijima-Ando et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Suppressor of
      Statement
      Reference

      miltJF03022/Scer\GAL4Mhc.PU is a suppressor | partially of visible phenotype of Pink1B9

      (Liu et al., 2012)

      miltJF03022/Scer\GAL4Mhc.PU is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Liu et al., 2012)
      Phenotype Manifest In
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      miltJF03022, Scer\GAL4GMR.PF is an enhancer of lamina phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Iijima-Ando et al., 2012)
      Suppressor of
      Statement
      Reference

      miltJF03022/Scer\GAL4Mhc.PU is a suppressor | partially of wing phenotype of Pink1B9

      (Liu et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of miltJF03022 under the control of Scer\GAL4Mhc.PU partially rescues the abnormal wing posture and flight defects of Pink1B9/Pink1B9 mutants.

      (Liu et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of miltJF03022 enhances neurodegeneration in the lamina of 3 day old flies expressing Hsap\MAPTScer\UAS.cWa under the control of Scer\GAL4GMR.PF.

      (Iijima-Ando et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      miltJF03022
      Name Synonyms
      Secondary FlyBase IDs
        References (7)