FlyBase Allele Report: Dmel\Hr51[Z0001]

General Information

Symbol

Dmel\Hr51^Z0001

Species

D. melanogaster

Name

FlyBase ID

FBal0239783

Feature type

allele

Associated gene

Dmel\Hr51

Associated Insertion(s)

Carried in Construct

Also Known As

unf^Z0001

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sung et al., 2009)

Progenitor genotype

Cytology

Description

Hr51^Z0001 carries a mutation in the second exon.

(Yaniv et al., 2012)

Amino acid replacement: G120R.

(Sung et al., 2009)

Nucleotide substitution: G312A.

(Sung et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:15,333,888..15,333,888 [+]

Nucleotide change:

G15333888A

Reported nucleotide change:

G312A

Amino acid change:

G120R | Hr51-PC

Reported amino acid change:

G120R

(Sung et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm

(Beuchle et al., 2012)

abnormal locomotor rhythm (with Df(2R)ED2426)

(Beuchle et al., 2012)

abnormal locomotor rhythm (with Hr51^X1)

(Beuchle et al., 2012)

abnormal neuroanatomy | somatic clone

(Yaniv et al., 2012)

female sterile (with Df(2R)ED2426)

(Sung et al., 2009)

male sterile (with Df(2R)ED2426)

(Sung et al., 2009)

visible

(Sung et al., 2009)

visible (with Df(2R)ED2426)

(Sung et al., 2009)

visible (with Hr51^X1)

(Sung et al., 2009)

Phenotype Manifest In

alpha/beta Kenyon cell | somatic clone

(Yaniv et al., 2012)

gamma Kenyon cell | somatic clone

(Yaniv et al., 2012)

lobe system of adult mushroom body

(Bates et al., 2010)

lobe system of adult mushroom body (with Df(2R)ED2426)

(Bates et al., 2010)

lobe system of adult mushroom body (with Hr51^X1)

(Bates et al., 2010)

wing

(Sung et al., 2009)

wing (with Df(2R)ED2426)

(Sung et al., 2009)

wing (with Hr51^X1)

(Sung et al., 2009)

Detailed Description

Statement

Reference

Homozygous Hr51^Z0001 mutant flies are arrhythmic in both LD conditions (12 hours light: 12 hours dark) and DD (constant darkness).

Hr51^Z0001/Df(2R)ED2426 mutant flies are arrhythmic in both LD conditions (12 hours light: 12 hours dark) and DD (constant darkness).

Hr51^X1/Hr51^Z0001 mutant flies are arrhythmic in both LD conditions (12 hours light: 12 hours dark) and DD (constant darkness).

(Beuchle et al., 2012)

Hr51^Z0001 mutant neuroblast clones exhibit γ-lobe defects with a decrease in innervation of the adult γ-lobe. α/β neurons exhibit normal morphology and show no signs of axon stalling.

Hr51^Z0001 heterozygous MARCM clones exhibit guidance defects in α/β neurons.

(Yaniv et al., 2012)

Hr51^Z0001/Df(2R)ED2426 hemizygous and Hr51^Z0001 homozygous mutants show a reduction of mushroom body (MB) lobes. α'/β' and α/β neurons of Hr51^Z0001/Df(2R)ED2426 hemizygotes project axons medially, but rarely project dorsal collateral axons. Dorsal lobes are observed more frequently in Hr51^Z0001 homozygotes.

Hr51^X1/Hr51^Z0001 heterozygotes exhibit a range of mushroom body (MB) phenotypes, for example, missing MB lobes.

(Bates et al., 2010)

75% of homozygous flies fail to eclose, while the remaining 25% eclose, but have unexpanded wings.

Hr51^Z0001/Df(2R)ED2426 animals eclose at the same frequency as control flies. 34% of the adults have unexpanded wings.

15% of Hr51^X1/Hr51^Z0001 flies fail to eclose and 62% eclose but have unexpanded wings.

(Sung et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hr51^X1

(Sung et al., 2009)

Partially rescued by

Df(2R)ED2426/Hr51^Z0001 is partially rescued by Scer\GAL4^ey-OK107/Hr51^UAS.cBa

(Bates et al., 2010)

Comments

Medial and dorsal mushroom body (MB) lobes are observed in all Hr51^Z0001/Df(2R)ED2426 animals expressing Hr51^Scer\UAS.cBa driven by Scer\GAL4^ey-OK107, but MB lobes appear thin and less robust in some rescued animals.

(Bates et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57324

w^*; Hr51^Z0001 bw¹/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hr51^Z0001

unf^Z0001

(Yaniv et al., 2012, Bates et al., 2010, Sung et al., 2009)

unf^z0001

(Kozlov et al., 2017, Beuchle et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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