unf, DHR51, unfulfilled, Nr2e3
nuclear receptor superfamily - a thiolate heme-binding protein - necessary for mushroom body axon extension and branching mutants modulate wing expansion and fertility through underlying neurological defects
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr51 using the Feature Mapper tool.
Hr51 transcripts are seen at all developmental stages on northern blots with different isoforms peaking at different times and in different tissues. Hr51 transcripts are detected by in situ hybridization in late embryos and larvae in a limited number of cells in the brain and ventral nerve cord. In late pupae, transcripts are observed in mushroom body neurons and in clusters along the ventral surface of the ventral nerve cord.
Hr51 was predominantly expressed in the nucleus in the s-LNvs, with the circadian peak occurring at ZT2 (2 hr after light-on)
under light-dark cycles. In the l-LNvs, Hr51 was expressed at somewhat lower levels without discernible circadian rhythms. Hr51 expression rhythms in the s-LNvs persisted in constant darkness (DD), suggesting that Hr51 accumulation rhythms are under the control of the circadian clock.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hr51 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hr51 CG16801
Hr51 is cell-autonomously required in γ-neurons for their ability to fully extend to the adult-specific lobe.
Hr51 is not required for the initial axon growth of any mushroom body neuron class.
Hr51 is not required cell-autonomously for initial axon guidance of growing γ neurons.
Nineteen percent of CG16801 mutant animals failed to eclose. Twenty-four percent of the mutant animals eclosed but failed to expand their wings. The remaining 57% of the mutant animals eclosed and expanded their wings. However, all of these animals were sterile, independent of gender.
The gene is named "unfulfilled", because some mutants successfully expand their wings while others fail to fulfill this potential.