unf, DHR51, unfulfilled, Nr2e3
nuclear receptor superfamily - a thiolate heme-binding protein - necessary for mushroom body axon extension and branching mutants modulate wing expansion and fertility through underlying neurological defects
Please see the JBrowse view of Dmel\Hr51 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr51 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Hr51 transcripts are seen at all developmental stages on northern blots with different isoforms peaking at different times and in different tissues. Hr51 transcripts are detected by in situ hybridization in late embryos and larvae in a limited number of cells in the brain and ventral nerve cord. In late pupae, transcripts are observed in mushroom body neurons and in clusters along the ventral surface of the ventral nerve cord.
Comment: displays circadian cycling
Hr51 was predominantly expressed in the nucleus in the s-LNvs, with the circadian peak occurring at ZT2 (2 hr after light-on)
Hr51 protein is localized to mushroom body neurons at all stages, from 6 hours after the beginning of larval development through adulthood.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hr51 in JBrowse2-74
2-78.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Hr51 is cell-autonomously required in γ-neurons for their ability to fully extend to the adult-specific lobe.
Hr51 is required for mushroom body γ-neuron axon regrowth following pruning.
Hr51 is not required for the initial axon growth of any mushroom body neuron class.
Hr51 is not required cell-autonomously for initial axon guidance of growing γ neurons.
Hr51 regulates both growth and guidance following pruning.
Mushroom body neurons require Hr51 to acquire their subtype identity.
Nineteen percent of CG16801 mutant animals failed to eclose. Twenty-four percent of the mutant animals eclosed but failed to expand their wings. The remaining 57% of the mutant animals eclosed and expanded their wings. However, all of these animals were sterile, independent of gender.
Source for identity of: Hr51 CG16801
The gene is named "unfulfilled", because some mutants successfully expand their wings while others fail to fulfill this potential.
