FlyBase Allele Report: Dmel\tmod[UAS.cBa]

General Information

Symbol

Dmel\tmod^UAS.cBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Bai

FlyBase ID

FBal0239923

Feature type

allele

Associated gene

Dmel\tmod

Associated Insertion(s)

Carried in Construct

P{UAS-tmod.B}

Also Known As

UAS-Tmod

Key Links

Transgenic product class

wild_type

(Bai et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bai et al., 2007)

Mutagen

in vitro construct

(Bai et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-tmod.B}

Cytology

Description

UAS regulatory sequences drive expression of tmod.

(Bai et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

tmod

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

lethal | embryonic stage, with Scer\GAL4^Mef2.PR

(Bai et al., 2007)

lethal | larval stage, with Scer\GAL4^Mef2.PR

(Bai et al., 2007)

Phenotype Manifest In

indirect flight muscle, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

M band, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

myofibril, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

sarcomere, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

striated muscle thin filament, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024, Molnár et al., 2014)

striated muscle thin filament, with Scer\GAL4^Mef2.PR

(Bai et al., 2007)

Z disc, with Scer\GAL4^Hk-UH3

(Farkas et al., 2024)

Detailed Description

Statement

Reference

Expression of tmod^Scer\UAS.cBa under the control of Scer\GAL4^UH3 results in shortening of thin filaments in the indirect flight muscles, so that they are no longer in perfect register.

(Molnár et al., 2014)

51% of animals expressing tmod^Scer\UAS.cBa under the control of Scer\GAL4^Mef2.PR die as embryos, while 49% die as larvae. The animals have muscle defects due to short thin filament lengths.

Primary cultured muscle cells isolated from embryos expressing tmod^Scer\UAS.cBa under the control of Scer\GAL4^Mef2.PR have shorter thin filament lengths than normal.

(Bai et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Mef2.PR, tmod^UAS.cBa has lethal | embryonic stage phenotype, enhanceable by sals^f07849

(Bai et al., 2007)

Other

Statement

Reference

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has abnormal size phenotype

(Farkas et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Mef2.PR, tmod^UAS.cBa has striated muscle thin filament phenotype, enhanceable by sals^f07849

(Bai et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^Hk-UH3, tmod^UAS.cBa has striated muscle thin filament phenotype, non-suppressible by DAAM^UASp.cMa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

Other

Statement

Reference

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has myofibril phenotype

(Farkas et al., 2024)

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has sarcomere phenotype

(Farkas et al., 2024)

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has striated muscle thin filament phenotype

(Farkas et al., 2024)

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has Z disc phenotype

(Farkas et al., 2024)

Scer\GAL4^Hk-UH3, sals^UAS.Tag:FLAG, tmod^UAS.cBa has indirect flight muscle phenotype

(Farkas et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

The thin filament shortening phenotype seen in the indirect flight muscles of animals expressing tmod^Scer\UAS.cBa under the control of Scer\GAL4^UH3 is unaffected by the co-expression of DAAM^{Scer\UAS.P\T.cMa}.

(Molnár et al., 2014)

sals^f07849 enhances the lethality cause by expression of tmod^Scer\UAS.cBa under the control of Scer\GAL4^Mef2.PR, such that a greater fraction of the animals die as embryos.

The reduction in thin filament length seen in primary cultured muscle cells isolated from embryos expressing tmod^Scer\UAS.cBa under the control of Scer\GAL4^Mef2.PR is increased if the animals are also carrying sals^f07849.

(Bai et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

tmod^Scer\UAS.cBa

tmod^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Bai

Secondary FlyBase IDs

References (3)

Report Sections

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