FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Polr2Dd189
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General Information
Symbol
Dmel\Polr2Dd189
Species
D. melanogaster
Name
FlyBase ID
FBal0239940
Feature type
allele
Associated gene
Dmel\Polr2D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Pankotai et al., 2005)
Progenitor genotype
P{lacW}moiS096713
(Pankotai et al., 2005)
Caused by aberration
Df(3R)d189
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in the removal of nucleotides +107 to -613 relative to the transcription start site of the Rpb4-Ada2a common first exon.

(Pankotai et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The Rpb4d189 mutation results in early lethality; Df(3R)d189 homozygotes in which the function of all genes affected by the deficiency except Rpb4 have been rescued using P{CaSpeR4-Dtl+Ada2a+} show first larval instar lethality.

      (Pankotai et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The puff in the 61C region induced by Scer\GAL4Act5C.PI-mediated expression of P{UAS-Fcp1.dsRNA.WIZ}61C remains readily detectable in Rpb4d189 homozygotes.

      (Ciurciu et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ada2ad189
      (Pankotai et al., 2005)
      Polr2Dd189
      Rpb4d189
      dAda2ad189
      (Ciurciu et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)