FB2026_02 , released June 18, 2026
Allele: Dmel\Traf4RNAi.UAS
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General Information
Symbol
Dmel\Traf4RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0239950
Feature type
allele
Associated gene
Dmel\Traf4
Associated Insertion(s)
Carried in Construct
P{UAS-Traf4.RNAi}
Also Known As
UAS-dTRAF1-IR
Key Links
Transgenic product class
RNAi_reagent
(Igaki et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Igaki et al., 2006)
Mutagen
in vitro construct
(Igaki et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Traf4.RNAi}
Cytology
Description

UAS regulatory sequences drive Traf4 coding sequences in an inverted repeat to allow cell-targeted generation of dsRNA for RNAi knockdown experiments.

(Igaki et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Traf4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by Ras85DV12.UAS, l(2)gl4
      (Igaki et al., 2006)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Traf4RNAi.UAS/Scer\GAL4GMR.PF is a suppressor | partially of visible phenotype of Ras85DKP

      (Wu et al., 2009)

      Traf4RNAi.UAS/Scer\GAL4GMR.PF is a suppressor of visible phenotype of BacA\p35GMR.PH, Ras85DKP

      (Wu et al., 2009)
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Traf4RNAi.UAS/Scer\GAL4GMR.PF is a suppressor | partially of eye phenotype of Ras85DKP

      (Wu et al., 2009)

      Traf4RNAi.UAS/Scer\GAL4GMR.PF is a suppressor of eye phenotype of BacA\p35GMR.PH, Ras85DKP

      (Wu et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      Traf4RNAi.UAS/Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Xue et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye phenotype in Ras85DKP mutant flies is partially suppressed by ectopic expression of Traf4dsRNA.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF.

      (Wu et al., 2009)

      The small-eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF is not suppressed by co-expression of Traf4dsRNA.Scer\UAS.

      (Xue et al., 2007)

      Expression of Traf4dsRNA.Scer\UAS (under the control of Scer\GAL4Act5C.PI) using the FLP/FRT system fails to suppress metastatic behaviour in l(2)gl4 mutants expressing Ras85DV12.Scer\UAS.

      (Igaki et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Traf4dsRNA.Scer\UAS under the control of Scer\GAL4 in flies expressing BacA\p35GMR.PH does not result in an eye phenotype.

      Expression of Traf4dsRNA.Scer\UAS (under the control of Scer\GAL4GMR.PF) and BacA\p35GMR.PH in a Ras85DKP mutant background strongly suppresses the eye phenotype.

      (Wu et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Traf4RNAi.UAS
      Traf4dsRNA.Scer\UAS
      Traf4dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)