FlyBase Allele Report: Dmel\Dlip3[C00008]

General Information

Symbol

Dmel\Dlip3^C00008

Species

D. melanogaster

Name

FlyBase ID

FBal0240199

Feature type

allele

Associated gene

Dmel\Dlip3

Associated Insertion(s)

P{EP}C00008

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}C00008

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | pharate adult stage P15, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

visible, with Scer\GAL4^Bx-MS1096

(Duong et al., 2008)

visible, with Scer\GAL4^GMR.PF

(Duong et al., 2008)

visible, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

visible, with Scer\GAL4^lz-gal4

(Duong et al., 2008)

Phenotype Manifest In

cone cell | increased number, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

crossvein, with Scer\GAL4^Bx-MS1096

(Duong et al., 2008)

eye, with Scer\GAL4^GMR.PF

(Duong et al., 2008)

eye, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

eye, with Scer\GAL4^lz-gal4

(Duong et al., 2008)

eye photoreceptor cell, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

ommatidium, with Scer\GAL4^GMR.PF

(Duong et al., 2008)

ommatidium, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

ommatidium, with Scer\GAL4^lz-gal4

(Duong et al., 2008)

primary pigment cell | increased number, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

rhabdomere, with Scer\GAL4^hs.2sev

(Duong et al., 2008)

wing vein, with Scer\GAL4^Bx-MS1096

(Duong et al., 2008)

Detailed Description

Statement

Reference

Expression of Dip3^C00008 under the control of either Scer\GAL4^elav.PLu or Scer\GAL4^sv.PJ has no effect on eye patterning.

Expression of Dip3^C00008 under the control of either Scer\GAL4^GMR.PF, Scer\GAL4^hs.2sev or Scer\GAL4^lz-gal4 results in smooth eyes that lack well-defined ommatidia.

Eyes of adults expressing Dip3^C00008 under the control of Scer\GAL4^hs.2sev have a reduced distance between the rhabdomere clusters and reduced numbers of rhabdomeres compared to wild type. Most ommatidia of mid-pupal eyes contain an extra cone cell and an extra primary pigment cell as well as fewer than the normal eight photoreceptors. Late pupal eye discs of these animals show increased cell death compared to wild type in inter-ommatidial cells but not in photoreceptor or cone cells.

Expression of Dip3^C00008 under the control of Scer\GAL4^Bx-MS1096 results in frequent loss of cross veins and truncation of longitudinal veins in the wing.

(Duong et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dlip3^C00008, Scer\GAL4^GMR.PF has visible phenotype, suppressible | heat sensitive by N^l1N-ts1

(Duong et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dlip3^C00008, Scer\GAL4^GMR.PF has eye phenotype, suppressible | heat sensitive by N^l1N-ts1

(Duong et al., 2008)

Dlip3^C00008, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible | heat sensitive by N^l1N-ts1

(Duong et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The smooth eye phenotype caused by expression of Dip3^C00008 under the control of Scer\GAL4^GMR.PF is partially suppressed by N^l1N-ts1 at 29[o]C; more interommatidial bristles and a clear demarcation between the ommatidia are seen.

(Duong et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dip3^C00008

Dlip3^C00008

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close