FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tadr1
Open Close
General Information
Symbol
Dmel\tadr1
Species
D. melanogaster
Name
FlyBase ID
FBal0240380
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: G532R.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G21080441M

Amino acid change:

G583R | tadr-PC; G583R | tadr-PD

Reported amino acid change:

G532R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The rhabdomeres of 1 day old mutant flies are virtually normal. 7 day old mutant flies show a severe decrease in the average size of the peripheral rhabdomeres, and the microvilli of most peripheral rhabdomeres are severely shortened (although they are not detached). 2 week old mutant flies contain detached and broken microvilli in peripheral rhabdomeres, and the overall length of the microvilli is much shorter than normal. The cell bodies of the peripheral rhabdomeres are severely shrunken. The central R7 rhabdomeres contain normally attached microvilli, although many of the rhabdomeres are deformed.

Mutant 7 day old flies raised completely in the dark have some irregularly shaped and/or smaller rhabdomeres, but the phenotype is much milder than mutant flies exposed to light.

Electroretinogram responses of 1 day old mutant flies have a smaller amplitude than those of wild-type flies. Electroretinogram responses of 7 day old mutant flies have a smaller amplitude and slower termination than those of wild-type flies.

In whole-cell current recordings in the dark, mutant photoreceptors have a normal background inward current and reversal potential. The mutant photoreceptors show a smaller light response compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

tadr1 has rhabdomere phenotype, suppressible by ninaE5

tadr1 has rhabdomere phenotype, suppressible by Gαq1

Additional Comments
Genetic Interactions
Statement
Reference

The average size of the peripheral rhabdomeres in 7 day old tadr1 ; ninaE5 flies is significantly larger than in tadr1 single mutants and is the same as in ninaE5 single mutants.

The average size of the peripheral rhabdomeres in 7 day old tadr1 ; Arr25 double mutant flies is smaller than that of tadr1 and Arr25 single mutants.

The reduced size of the peripheral rhabdomeres in 7 day old tadr1 flies is suppressed if they are also mutant for Gα49B1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
tadr1
Name Synonyms
Secondary FlyBase IDs
    References (1)