FB2026_02 , released June 18, 2026
Allele: Dsim\Nmy1427
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General Information
Symbol
Dsim\Nmy1427
Species
D. simulans
Name
FlyBase ID
FBal0240516
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
nmy, SSR12-2-7
Nature of the Allele
Progenitor genotype
Cytology
Description

Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus, and the loss of most of the sequence located between the inverted repeats, except for a 93bp element in reverse orientation.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Dsim\Nmy1427 males show sex ratio distortion; the progeny of such males show a female-biased sex ratio. The expressivity of the sex ratio distortion is inversely correlated to the temperature; at 18[o]C, the sex ratio of the progeny can reach as high as 93%, whereas at 25[o]C, the sex ratio decreases to approximately 60%. Only the temperature at which the males are reared has an effect on the sex ratio distortion. The age of the males also has a much smaller, but also significant, effect on the sex ratio distortion.

Dsim\Nmy1427 males show abnormalities in various stages of spermatogenesis. The mutant spermatid nuclei start to accumulate nucleoplasmic vacuoles at the late onion stage. At the early elongation stage, some mutant spermatid nuclei have very pronounced nucleoplasmic vacuoles, although the alignment of rows of microtubules along the fenestrated portion of the nuclear membrane appears normal. Later, in the post-elongation period, nuclear condensation appears disrupted, and rupture of the nuclear membrane is sometimes seen. During individualisation, the nucleoplasmic vacuoles within abnormal mutant spermatids are squeezed into the tail region, apparently causing physical difficulty for the cystic bulge to pass through. These abnormal tails remain in the syncytium, which other tails are individualised and separated.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Dsim\DoxΔ105 Dsim\Nmy1427 males do not show sex ratio distortion (the sex ratio of the progeny of double mutant males raised at 16[o]C is 54%). All stages of spermatid maturation appear to be normal in these double mutant males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Dsim\Nmy1427 is segregating in the D.simulans sim2 strain with a frequency of 6.1%

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)