FB2026_02 , released June 18, 2026
Allele: Dmel\RhoGAP18B2
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General Information
Symbol
Dmel\RhoGAP18B2
Species
D. melanogaster
Name
FlyBase ID
FBal0240543
Feature type
allele
Associated gene
Dmel\RhoGAP18B
Associated Insertion(s)
P{GawB}RhoGAP18B2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Rothenfluh et al., 2006)
Progenitor genotype
Associated Insertion(s)
P{GawB}RhoGAP18B2
Cytology
Description

A P-element is inserted 5' of the RD transcription start site, in the ORF of the RC transcript.

(Rothenfluh et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Rothenfluh et al., 2006)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RhoGAP18B2 mutants exhibit resistance to ethanol-induced sedation measured with either a locomotor tracking system or a loss-of-righting (LOR) test. Ethanol absorption is normal in RhoGAP18B2 flies, which also perform normally in various behavioural assays, including those measuring sensitivity to CO[[2]]-induced sedation, nicotine toxicity, spontaneous locomotion, circadian rhythms, and negative geotaxis. RhoGAP18B2 flies also show increased resistance to the acute effects of nicotine and cocaine.

      RhoGAP18B2 exhibits resistance to ethanol-induced sedation.

      (Rothenfluh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RhoGAP18B2
      whir2
      (Rothenfluh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)