FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mef2UAS.Tag:MYC
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General Information
Symbol
Dmel\Mef2UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0240572
Feature type
allele
Associated gene
Dmel\Mef2
Associated Insertion(s)
Carried in Construct
P{UAS-Mef2.6xMyc}
Key Links
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
in vitro construct
(Deng et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Mef2.6xMyc}
Cytology
Description

UAS regulatory sequences drive expression of Mef2 which is tagged with Tag:MYC.

(Deng et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mef2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR result in one extra row of Mef2-positive cardiac cells in the embryo, whereas the tin-positive cardiac cells are not affected.

      (Deng et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of vgScer\UAS.T:Ivir\HA1 and Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR in the embryo has a synergistic effect on cardiac cells; there are two extra rows of Mef2-positive cardiac cells and six tin-positive cardiac cells per hemisegment, with many more tin-positive pericardial cells.

      Co-expression of sdScer\UAS.T:Zzzz\FLAG and Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR in the embryo results in a cardiac cell phenotype similar to that of embryos expressing sdScer\UAS.T:Zzzz\FLAG alone under the control of Scer\GAL4Mef2.PR.

      (Deng et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mef2Scer\UAS.T:Hsap\MYC
      Mef2UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)