FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NT1RNAi.pro.UAS
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General Information
Symbol
Dmel\NT1RNAi.pro.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0240745
Feature type
allele
Associated gene
Dmel\NT1
Associated Insertion(s)
Carried in Construct
P{UAS-proNT1.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Zhu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Zhu et al., 2008)
Mutagen
in vitro construct
(Zhu et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-proNT1.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of inverted repeat sequences corresponding to the pro-domain region of NT1.

(Zhu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
NT1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Targeted expression of NT1dsRNA.pro.Scer\UAS in the CNS midline (under the control of Scer\GAL4sim.PS) in a NT141 heterozygous background results in a significant increase in apoptosis throughout the CNS cortex compared to controls at embryonic stage 17.

      Targeted expression of NT1dsRNA.pro.Scer\UAS in all the neurons (under the control of Scer\GAL4elav-C155) does not significantly affect axon guidance, whereas expression in the muscle (under the control of Scer\GAL4how-24B) significantly alters axon guidance and routing.

      Targeted expression of NT1IR.pro.Scer\UAS in the CNS midline (under the control of Scer\GAL4sim.PS) in a NT141.Δ.w heterozygous background results in a significant increase in apoptosis throughout the CNS cortex compared to controls at embryonic stage 17.

      Targeted expression of NT1IR.pro.Scer\UAS in all the neurons (under the control of Scer\GAL4elav-C155) does not significantly affect axon guidance, whereas expression in the muscle (under the control of Scer\GAL4how-24B) significantly alters axon guidance and routing.

      (Zhu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      NT1IR.pro.Scer\UAS knocks-down all NT1 transcripts.

      (Zhu et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      NT1IR.pro.Scer\UAS
      NT1RNAi.pro.UAS
      NT1dsRNA.pro.Scer\UAS
      NT1dsRNA.pro.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)