FB2026_02 , released June 18, 2026
Allele: Dmel\Diap1C406Y.αTub84B
Open Close
General Information
Symbol
Dmel\Diap1C406Y.αTub84B
Species
D. melanogaster
Name
FlyBase ID
FBal0240770
Feature type
allele
Associated gene
Dmel\Diap1
Associated Insertion(s)
Carried in Construct
P{tub-DIAP1C406Y}
Key Links
Transgenic product class
missense_variant
(Ditzel et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ditzel et al., 2008)
Mutagen
in vitro construct
(Ditzel et al., 2008)
Progenitor genotype
Carried in construct
P{tub-DIAP1C406Y}
Cytology
Description

A αTub84B promoter drives expression of th coding sequences containing an amino acid replacement in the RING domain.

(Ditzel et al., 2008)

Amino acid replacement: C406Y.

(Ditzel et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
αTub84B
Encoded product / tool
Diap1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Diap1C406Y.αTub84B is a non-suppressor of increased cell death phenotype of rprGMR.PW

      (Ditzel et al., 2008)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Diap1C406Y.αTub84B is a non-suppressor of eye phenotype of rprGMR.PW

      (Ditzel et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of thC406Y.αTub84B, which lacks a functional RING domain, fails to inhibit the small-eye phenotype observed in rprGMR.PW mutants.

      (Ditzel et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Diap1C406Y.αTub84B
      thC406Y.αTub84B
      Name Synonyms
      Secondary FlyBase IDs
        References (1)