FlyBase Allele Report: Dmel\grh[JF02305]

General Information

Symbol

Dmel\grh^JF02305

Species

D. melanogaster

Name

FlyBase ID

FBal0240795

Feature type

allele

Associated gene

Dmel\grh

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02305}

Also Known As

UAS-grh^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02305}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02305

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates acute myeloid leukemia

modeled by Hsap\HOXA9::Hsap\NUP98^WT.UAS

(Gavory et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

partially lethal, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

visible | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

Phenotype Manifest In

embryonic/larval posterior spiracle | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

embryonic/larval tracheal dorsal trunk | first instar larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

Detailed Description

Statement

Reference

Animals expressing grh^JF02305 under the control of Scer\GAL4^grh.D4 are lethal, show defects in larval dorsal trunk elongation (resulting in internalization of posterior spiracles into the body cavity) and the larvae are smaller than age-matched controls.

(Wingen et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

grh^JF02305, Scer\GAL4^ey.PH is a suppressor | partially of decreased size | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

grh^JF02305, Scer\GAL4^ey.PH is a suppressor | partially of visible | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

grh^JF02305, Scer\GAL4^ey.PH is a suppressor | partially of eye phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28820

y¹ v¹; P{TRiP.JF02305}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

grh^JF02305

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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