FlyBase Allele Report: Dmel\Flo2[UAS.cHa]

General Information

Symbol

Dmel\Flo2^UAS.cHa

Species

D. melanogaster

Name

FlyBase ID

FBal0240975

Feature type

allele

Associated gene

Dmel\Flo2

Associated Insertion(s)

Carried in Construct

P{UAS-Flo2.H}

Key Links

Transgenic product class

cDNA

(Hoehne et al., 2005)

wild_type

(Hoehne et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hoehne et al., 2005)

wild_type

(Hoehne et al., 2005)

Mutagen

in vitro construct

(Hoehne et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Flo2.H}

Cytology

Description

UASt regulatory sequences drive expression of Flo2 coding sequences corresponding to the clone LD02581.

(Hoehne et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Flo2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^MZ1369

(Hoehne et al., 2005)

macrochaeta, with Scer\GAL4^MZ1369

(Hoehne et al., 2005)

ocellus, with Scer\GAL4^MZ1369

(Hoehne et al., 2005)

wing, with Scer\GAL4^MZ1369

(Hoehne et al., 2005)

Detailed Description

Statement

Reference

Overexpression of Flo-2^Scer\UAS.cHa under the control of Scer\GAL4^MZ1369 results in compound phenotypic defects including abnormal eyes, ocelli, bristles and wings.

(Hoehne et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Flo2^UAS.cHa, Scer\GAL4^MZ1369 has eye phenotype, enhanceable by Flo1^UAS.cHa, Scer\GAL4^MZ1369

(Hoehne et al., 2005)

Flo2^UAS.cHa, Scer\GAL4^MZ1369 has ocellus phenotype, enhanceable by Flo1^UAS.cHa, Scer\GAL4^MZ1369

(Hoehne et al., 2005)

Flo2^UAS.cHa, Scer\GAL4^MZ1369 has macrochaeta phenotype, enhanceable by Flo1^UAS.cHa, Scer\GAL4^MZ1369

(Hoehne et al., 2005)

Flo2^UAS.cHa, Scer\GAL4^MZ1369 has wing phenotype, enhanceable by Flo1^UAS.cHa, Scer\GAL4^MZ1369

(Hoehne et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Flo-2^Scer\UAS.cHa and Flo^Scer\UAS.cHa under the control of Scer\GAL4^MZ1369 results in compound phenotypic defects including abnormal eyes, ocelli, bristles and wings. Wings exhibit a highly variable but severe mutant phenotype, including blisteriing and melanotic cells. Mutant eye discs display a variable number of cone cells andprimary pigment cells per ommatidium, errors in number and positioning of the bristle complexes and mild cell sorting defects. The type of defects caused by Scer\GAL4^MZ1369-driven misexpression of Flo-2^Scer\UAS.cHa alone or in tandem with Flo^Scer\UAS.cHa are largely indistinguishable, although flies overexpressing both proteins display a tendency towards more pronounced defects.

(Hoehne et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Flo-2^Scer\UAS.cHa

Flo2^Scer\UAS.cHa

Flo2^UAS.cHa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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