FlyBase Allele Report: Dmel\kek5[Δ1]

General Information

Symbol

Dmel\kek5^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0241006

Feature type

allele

Associated gene

Dmel\kek5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Evans et al., 2009)

Mutagen

P-element activity

(Evans et al., 2009)

Progenitor genotype

P{GT1}kek5^BG02535

(Evans et al., 2009)

Cytology

Description

An 840 bp deletion beginning 426 bp upstream and ending 58 bp downstream of exon 1 of kek5 resulting from the imprecise excision of P{GT1}kek5^BG02535.

(Evans et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:19,352,803..19,353,641 [+]

Comment:

An 840 base deletion extending from 426 bases upstream to 58 bases downstream of exon 1 of kek5 as defined by GB:AY195738.

(Evans et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Evans et al., 2009)

short lived | recessive

(Evans et al., 2009)

visible (with Df(1)Exel7468)

(Evans et al., 2009)

visible (with Df(1)JA27)

(Evans et al., 2009)

visible (with kek5^fe148)

(Evans et al., 2009)

visible | recessive

(Evans et al., 2009)

Phenotype Manifest In

crossvein

(Evans et al., 2009)

crossvein (with Df(1)Exel7468)

(Evans et al., 2009)

crossvein (with Df(1)JA27)

(Evans et al., 2009)

crossvein (with kek5^fe148)

(Evans et al., 2009)

wing blade

(Evans et al., 2009)

wing blade (with Df(1)Exel7468)

(Evans et al., 2009)

wing blade (with Df(1)JA27)

(Evans et al., 2009)

Detailed Description

Statement

Reference

Homozygous kek5^Δ1 mutants produce fertile adults. However, the mutant imagos exhibit decreased viability.

kek5^Δ1 and kek5^fe148/kek5^Δ1 mutant wings exhibit defects in crossvein patterning with a penetrance of about 25-30%. The frequency of crossvein defects is enhanced by hemizygosity over Df(1)Exel7468 or Df(1)JA27. kek5^Δ1 mutant wing defects include truncated or missing posterior crossvein, twigging or forking of the crossvein, ectopic posterior crossvein material, meandering posterior crossvein and ectopic crossveins around the anterior crossvein. The anterior crossvein is rarely deleted or truncated in kek5^Δ1 mutants; more often partial or full-length ectopic crossveins appear adjacent to the anterior crossvein.

kek5^Δ1 mutant wings display blisters at low frequency (less than 5%) when homo- or hemizygous, or when either placed over deficiencies for the region Df(1)Exel7468 or Df(1)JA27.

(Evans et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

kek5^Δ1

(Evans et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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