FB2026_02 , released June 18, 2026
Allele: Dmel\wupAUAS.L9
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General Information
Symbol
Dmel\wupAUAS.L9
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Sahota
FlyBase ID
FBal0241062
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
Carried in Construct
P{UAS-wupA.L9}
Key Links
Transgenic product class
wild_type
(Sahota et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sahota et al., 2009)
Mutagen
in vitro construct
(Sahota et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-wupA.L9}
Cytology
Description

UASt regulatory sequences drive expression of the L9/wupA-RA isoform of wupA.

(Sahota et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
wupA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      wupAUAS.L9 rescues wupAfliH

      (Firdaus et al., 2015)
      Partially rescues

      wupAUAS.L9/Scer\GAL4Hk-UH3 partially rescues wupAhdp-3

      (Singh et al., 2014)

      wupAUAS.L9 partially rescues wupAPL87

      (Sahota et al., 2009)

      wupAUAS.L9 partially rescues wupAPG31

      (Sahota et al., 2009)

      wupAUAS.L9 partially rescues wupA23437

      (Sahota et al., 2009)
      Comments

      Targeted overexpression of wupAScer\UAS.L9 under the control of Scer\GAL4Hk-UH3, which expresses in developing indirect flight muscles (IFMs), brings about rescue of the wupAfliH muscle phenotype. Six dorsal longitudinal muscles (DLMs) are seen with normal banding pattern sarcomeres. Rescued flies also show functional recovery of the muscles as indicated by their flight ability.

      (Firdaus et al., 2015)

      Expression of wupAScer\UAS.L9 under the control of Scer\GAL4Hk-UH3 rescues the structural defects seen in the indirect flight muscles of hemizygous wupAhdp-3 mutants, though not completely. Rescued hemizygous flies are completely flightless and the size of the myofibrils is comparatively smaller compared to controls. Rescued heterozygous flies show a better myofibrillar structure where the sarcomeres look near-normal, but are still unable to fly.

      (Singh et al., 2014)

      wupAScer\UAS.L9 driven by Scer\GAL4αTub84B.PL rescues the embryonic lethality of homozygous wupA23437, although approximately 40% of pupae fail to eclose and display a cryptocephalic phenotype.

      wupAScer\UAS.L9 driven by Scer\GAL4αTub84B.PL rescues the embryonic lethality of homozygous wupAPG31.

      wupAScer\UAS.L9 driven by Scer\GAL4αTub84B.PL rescues the embryonic lethality of homozygous wupAPL87.

      (Sahota et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      wupAScer\UAS.L9
      wupAUAS.L9
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Sahota
      Secondary FlyBase IDs
        References (3)