FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaE+t2.747
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General Information
Symbol
Dmel\ninaE+t2.747
Species
D. melanogaster
Name
FlyBase ID
FBal0241242
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
P{ninaE.2747.WT}
Also Known As
Rh1WT
Key Links
Transgenic product class
genomic_DNA
(Galy et al., 2005)
wild_type
(Galy et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Galy et al., 2005)
wild_type
(Galy et al., 2005)
Mutagen
in vitro construct
(Galy et al., 2005)
Progenitor genotype
Carried in construct
P{ninaE.2747.WT}
Cytology
Description

1747bp of ninaE coding sequence and approximately 1kb of ninaE upstream sequence are cloned into CasPer4.

(Galy et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
ninaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ninaE+t2.747 leads to progressive retinal degeneration, with a significant decrease in the number of photoreceptor neurons in adults after 30, but not 20, days of light exposure, nor when reared in the dark for 30 days; but these flies do not exhibit significant defects in phototaxis, geotaxis, or photoreceptor depolarization after light stimulation, as compared to controls.

      (Griciuc et al., 2010)

      ninaEWT.+t2747 transgenic rhabdomeres raised under day/night conditions show no signs of photoreceptor degeneration at eclosion.

      ninaEWT.+t2747 flies show positive phototaxis, both at days 1 and 14, indicating that the ninaEWT.+t2747 transgene does not modify fly vision throughout life.

      (Galy et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ninaE+t2.747 in a TER9426-8/+ background does not result in defects in phototaxis or geotaxis after 20 or 30 days of light exposure, and does not result in a defect in photoreceptor depolarization after 30 or 45 days of light exposure, as compared to controls.

      (Griciuc et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ninaE+t2.747 rescues ninaE17

      (Galy et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ninaE+t2.747
      ninaEWT.+t2747
      Name Synonyms
      Secondary FlyBase IDs
        References (4)