FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lztr1MB12128
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General Information
Symbol
Dmel\Lztr1MB12128
Species
D. melanogaster
Name
FlyBase ID
FBal0241298
Feature type
allele
Associated gene
Dmel\Lztr1
Associated Insertion(s)
Mi{ET1}Lztr1MB12128
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}Lztr1MB12128
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Lztr1MB12128 hemizygous males and homozygous females show decreased sleep only during night-time, with increased sleep latency; males show more but shorter day-time sleep bouts and decreased night-time motion bout activity. Despite of unchanged circadian rhythm length, when looking at the strength of the circadian clock, there is reduction in the fraction of rhythmic flies and reduced strength of rhythmicity.

        (Maurer et al., 2020)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Lztr1MB12128 has decreased sleep | male phenotype, suppressible by Rdl[+]/RdlCB2

        (Maurer et al., 2020)

        Lztr1MB12128 has abnormal sleep | male phenotype, suppressible by Rdl[+]/RdlCB2

        (Maurer et al., 2020)
        Suppressor of
        Statement
        Reference

        Lztr1MB12128 is a suppressor | partially of abnormal sleep | dominant | male phenotype of RdlCB2

        (Maurer et al., 2020)
        NOT Suppressor of
        Statement
        Reference

        Lztr1MB12128 is a non-suppressor of increased sleep | dominant | male phenotype of RdlCB2

        (Maurer et al., 2020)
        Other
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Lztr1MB12128/+, Nf1unspecified/+ females show decreased day-time and night-time sleep, with decreased day-time and night-time sleep bout duration.

        (Maurer et al., 2020)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG3711MB12128
        (Bellen, 2010.1.28)
        Lztr1MB12128
        nowl1
        (Maurer et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)