FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AMPKα2
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General Information
Symbol
Dmel\AMPKα2
Species
D. melanogaster
Name
FlyBase ID
FBal0241420
Feature type
allele
Associated gene
Dmel\AMPKα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Swick et al., 2013)
Mutagen
ethyl methanesulfonate
(Swick et al., 2013)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,377,299..1,377,299 [+]
Nucleotide change:

C1377299T

Amino acid change:

Q295term | AMPKalpha-PA; Q295term | AMPKalpha-PB; Q295term | AMPKalpha-PC

Reported amino acid change:

Q295term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Swick et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants display a completely penetrant phenotype of significantly enlarged plasma membrane domains in dendrites but not in axonal compartments of da neurons in second instar larvae.

      (Swick et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AMPKα2
      SNF1A2
      ampkα2
      (Swick et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)