FlyBase Allele Report: Hsap\L1CAM[RSLE-.UAS]

General Information

Symbol

Hsap\L1CAM^RSLE-.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0241455

Feature type

allele

Associated gene

Hsap\L1CAM

Associated Insertion(s)

Carried in Construct

P{UAS-L1CAM.RSLE-}

Key Links

Transgenic product class

wild_type

(Kristiansen et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kristiansen et al., 2005)

Mutagen

in vitro construct

(Kristiansen et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-L1CAM.RSLE-}

Cytology

Description

UASt regulatory sequences drive expression of the non-neuronal RSLE- isoform of Hsap\L1CAM.

(Kristiansen et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\L1CAM

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^MS1075 results in a low but not significant level of bristle mechanosensory (BM) axonal defects.

(Nagaraj et al., 2009)

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^MS1075 induces few phenotypic alterations. No ectopic expression alterations are found in the ocellar sensory system and only a weak gain of function phenotype is observed in the wing.

(Kristiansen et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of abnormal neurophysiology | adult stage phenotype of Nrg^180ΔFIGQY, Nrg^l4

(Kudumala et al., 2013)

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Nrg^180ΔFIGQY, Nrg^l4

(Kudumala et al., 2013)

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Nrg⁸⁴⁹

(Kudumala et al., 2013)

Scer\GAL4^MS1075/Hsap\L1CAM^RSLE-.UAS is a suppressor of abnormal neuroanatomy phenotype of Nrg^l3

(Nagaraj et al., 2009, Kristiansen et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of giant fiber neuron | adult stage phenotype of Nrg⁸⁴⁹

(Kudumala et al., 2013)

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of giant fiber neuron | adult stage phenotype of Nrg^180ΔFIGQY, Nrg^l4

(Kudumala et al., 2013)

Hsap\L1CAM^RSLE-.UAS/Scer\GAL4^shot-OK307 is a suppressor of adult neuromuscular junction phenotype of Nrg^180ΔFIGQY, Nrg^l4

(Kudumala et al., 2013)

Scer\GAL4^MS1075/Hsap\L1CAM^RSLE-.UAS is a suppressor of ocellar nerve phenotype of Nrg^l3

(Nagaraj et al., 2009, Kristiansen et al., 2005)

Scer\GAL4^MS1075/Hsap\L1CAM^RSLE-.UAS is a suppressor of mechanosensory neuron phenotype of Nrg^l3

(Nagaraj et al., 2009)

Scer\GAL4^MS1075/Hsap\L1CAM^RSLE-.UAS is a suppressor | partially of mechanosensory neuron phenotype of Nrg^l3

(Kristiansen et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^OK307 significantly suppresses the giant fibre axon guidance defects seen in Nrg⁸⁴⁹ mutant flies.

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^OK307 suppresses the Giant Fibre (GF)-Trochanteral Muscle (TTM) synaptic defects seen in flies expressing Nrg^180ΔFIGQY in a Nrg^l4 mutant background; there is an increase in following frequencies after a train of stimulations at 100Hz and response latency is decreased. All flies observed show TTM responses upon GF stimulation. The morphology of the synaptic terminals is restored.

(Kudumala et al., 2013)

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^MS1075 suppresses the bristle mechanosensory (BM) axonal defects seen in Nrg^l3 mutant flies.

(Nagaraj et al., 2009)

Expression of Hsap\L1CAM^{RSLE-.Scer\UAS} under the control of Scer\GAL4^MS1075 in Nrg^l3 mutant individuals rescues the axonal defects in OP axons, along with slightly reducing the level of BM axon defects.

(Kristiansen et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\L1CAM^{RSLE-.Scer\UAS}

Hsap\L1CAM^RSLE-.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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