FlyBase Allele Report: Dmel\Cisd[G6528]

General Information

Symbol

Dmel\Cisd^G6528

Species

D. melanogaster

Name

FlyBase ID

FBal0241602

Feature type

allele

Associated gene

Dmel\Cisd

Associated Insertion(s)

P{EP}Cisd^G6528

Carried in Construct

Also Known As

cisd2^G6528

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2020)

hypomorphic allele - molecular evidence

(Jones et al., 2014)

Mutagen

P-element activity

(Bellen, 2010.2.16)

Progenitor genotype

Associated Insertion(s)

P{EP}Cisd^G6528

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:29,223,313..29,223,313 [+]

(Chen et al., 2020, Bellen, 2010.2.16)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Chen et al., 2020)

long lived

(Chen et al., 2020)

viable

(Huynh et al., 2019)

Phenotype Manifest In

flight muscle cell | adult stage

(Chen et al., 2020)

mitochondrion | adult stage

(Chen et al., 2020)

Detailed Description

Statement

Reference

Cisd2^G6528 homozygous adults exhibit smaller and rounder mitochondria in flight muscles; unlike controls, these mitochondria fail to accumulate vesicles with age. 3-weeks-old adult show increased climbing ability compared to controls.

(Chen et al., 2020)

Negative geotaxis is not altered in Cisd2^G6528 flies.

(Jones et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Cisd^G6528 is an enhancer of ommatidium phenotype of Cln3^UAS.cTa, Scer\GAL4^GMR.PU

(Jones et al., 2014)

Cisd^G6528 is an enhancer of interommatidial bristle phenotype of Cln3^UAS.cTa, Scer\GAL4^GMR.PU

(Jones et al., 2014)

Suppressor of

Statement

Reference

Cisd^G6528 is a suppressor of ommatidium phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PU

(Jones et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Negative geotaxis is not altered in flies expressing Ppt1^Scer\UAS.cKa via Scer\GAL4^elav.PU in a Cisd2^G6528 background.

Negative geotaxis behaviour is substantially reduced in flies expressing cln3^Scer\UAS.cTa via Scer\GAL4^elav.PU in a Cisd2^G6528 background.

(Jones et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30170

w¹¹¹⁸; P{EP}Cisd^G6528

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG1458^G6528

(Bellen, 2010.2.16)

Cisd2^G6528

(Huynh et al., 2019)

Cisd^G6528

cisd2^G6528

(Jones et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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