FB2026_02 , released June 18, 2026
Allele: Dmel\nemy45
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General Information
Symbol
Dmel\nemy45
Species
D. melanogaster
Name
FlyBase ID
FBal0241703
Feature type
allele
Associated gene
Dmel\nemy
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Iliadi et al., 2008)
Progenitor genotype
P{lacW}nemyP153
(Iliadi et al., 2008)
Cytology
Description

Expression of of the nemy-RA transcript is significantly reduced, while expression of the remaining transcripts is unaffected.

(Knight et al., 2015)

Imprecise excision of the progenitor insertion, resulting in a deletion that removes 743bp of the longest splice form of nemy, including the first exon.

(Iliadi et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:12,669,472..12,670,213 [-]
Comment:

A deletion associated with the imprecise excision of P{lacW}nemyP153.

(Iliadi K., 2012.11.29)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nemy45/nemy45 third instar larvae show no significant change in the amplitude of miniature excitatory junction potentials (mEJPs), but did show a significant increase in mEJP frequency, at the neuromuscular junction compared to controls. nemy45/nemy45 larvae show a significant increase in amplitude of evoked EJPs and quantal content compared to controls. nemy45/nemy45 larvae do not show a significant change in bouton number at the NMJ compared to controls. Controls show mild paired pulse potentiation at short inster-stimulus intervals, whereas nemy45/nemy45 larvae show paired pulse depression.

      (Knight et al., 2015)

      Mutant flies show a significant defect in 3 hour memory (assayed 3 hours after a single training session in the odor-shock paradigm) compared to controls.

      (Iliadi et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nemy45
      (Knight et al., 2015, Iliadi K., 2012.11.29, Iliadi et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)